The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo.
about
Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.Analysis of aggregated cell-cell statistical distances within pathways unveils therapeutic-resistance mechanisms in circulating tumor cells.Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies.Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism.Targeting sphingosine-1-phosphate signaling for cancer therapy.Therapeutic implications of bioactive sphingolipids: A focus on colorectal cancer.Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640.Examining the Role of Sphingosine Kinase-2 in the Regulation of Endothelial Cell Barrier Integrity.Cell cycle-coupled expansion of AR activity promotes cancer progression.Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress.Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells.Sphingosine kinase 2 and multiple myelomaThe Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer.Development of 1,2,3-Triazole-Based Sphingosine Kinase Inhibitors and Their Evaluation as Antiproliferative Agents.The sphingosine kinase 2 inhibitor ABC294640 displays anti-non-small cell lung cancer activities in vitro and in vivo.Sphingolipid metabolism in cancer signalling and therapy.Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice.Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT.Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3.A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors.
P2860
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P2860
The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo.
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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name
The Sphingosine Kinase 2 Inhib ...... eramides In Vitro and In Vivo.
@ast
The Sphingosine Kinase 2 Inhib ...... eramides In Vitro and In Vivo.
@en
type
label
The Sphingosine Kinase 2 Inhib ...... eramides In Vitro and In Vivo.
@ast
The Sphingosine Kinase 2 Inhib ...... eramides In Vitro and In Vivo.
@en
prefLabel
The Sphingosine Kinase 2 Inhib ...... eramides In Vitro and In Vivo.
@ast
The Sphingosine Kinase 2 Inhib ...... eramides In Vitro and In Vivo.
@en
P2093
P2860
P1476
The Sphingosine Kinase 2 Inhib ...... eramides In Vitro and In Vivo.
@en
P2093
Charles D Smith
Christina Voelkel-Johnson
E Ellen Jones
Elizabeth Garrett-Mayer
Heather Venant
Jacqueline M Kraveka
Mehrdad Rahmaniyan
Michael B Lilly
Richard R Drake
P2860
P304
P356
10.1158/1535-7163.MCT-15-0279
P577
2015-10-22T00:00:00Z