DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice.
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Genome Engineering with TALE and CRISPR Systems in NeuroscienceExploring the nexus of Alzheimer's disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer's Association & Alzheimer's Drug Discovery Foundation.Do DNA Double-Strand Breaks Drive Aging?Levetiracetam mitigates doxorubicin-induced DNA and synaptic damage in neuronsCyclin A2 promotes DNA repair in the brain during both development and aging.Herpes Simplex Virus-Type1 (HSV-1) Impairs DNA Repair in Cortical Neurons.LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining.Tumor suppressor menin is required for subunit-specific nAChR α5 transcription and nAChR-dependent presynaptic facilitation in cultured mouse hippocampal neurons.Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease.Two proteolytic fragments of menin coordinate the nuclear transcription and postsynaptic clustering of neurotransmitter receptors during synaptogenesis between Lymnaea neurons.A genome-wide association study of cognitive function in Chinese adult twins.Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice.Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative DisordersThe transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease.The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons.Physiological Roles of DNA Double-Strand Breaks.Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.Genome integrity and disease prevention in the nervous system.RAD52 is required for RNA-templated recombination repair in post-mitotic neurons.DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice.Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies.A BRCA1-Dependent DNA Damage Response in the Regenerating Adult Peripheral Nerve Milieu.mRNA Processing Factor CstF-50 and Ubiquitin Escort Factor p97 Are BRCA1/BARD1 Cofactors Involved in Chromatin Remodeling during the DNA Damage Response.Induced Cre-mediated knockdown of Brca1 in skeletal muscle reduces mitochondrial respiration and prevents glucose intolerance in adult mice on a high-fat diet.The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?Plasma Amyloid-Beta Levels in Patients with Different Types of Cancer.Genome instability in Alzheimer disease.Altered DNA repair; an early pathogenic pathway in Alzheimer's disease and obesity.Cognitive Impairment in Chronic Obstructive Pulmonary Disease (COPD): Possible Utility of Marine Bioactive CompoundsReal-world health services utilisation and outcomes after and testing in Ontario, Canada: the What Comes Next Cohort Study protocol
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P2860
DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
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2015年學術文章
@zh-hant
name
DNA repair factor BRCA1 deplet ...... rs cognitive function in mice.
@ast
DNA repair factor BRCA1 deplet ...... rs cognitive function in mice.
@en
type
label
DNA repair factor BRCA1 deplet ...... rs cognitive function in mice.
@ast
DNA repair factor BRCA1 deplet ...... rs cognitive function in mice.
@en
prefLabel
DNA repair factor BRCA1 deplet ...... rs cognitive function in mice.
@ast
DNA repair factor BRCA1 deplet ...... rs cognitive function in mice.
@en
P2093
P2860
P356
P1476
DNA repair factor BRCA1 deplet ...... rs cognitive function in mice.
@en
P2093
Biljana Djukic
Daniel H Kim
Joseph Knox
Kaitlyn Ho
Lennart Mucke
Mariel Finucane
Mark Evans
Nino Devidze
Praveen Taneja
P2860
P2888
P356
10.1038/NCOMMS9897
P407
P577
2015-11-30T00:00:00Z
P6179
1027594343