Delayed thymocyte development induced by augmented expression of p56lck.
about
Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte developmentDevelopment of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck miceLck SH3 domain function is required for T-cell receptor signals regulating thymocyte development.C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases.Lck unique domain influences Lck specificity and biological function.The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds.Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness.DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH.Dysregulation of the protein tyrosine kinase LCK in lymphoproliferative disorders and in other neoplasias.Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.A dominant-negative transgene defines a role for p56lck in thymopoiesis.Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4+CD8+ thymocytes into mature T cellsThe protein tyrosine kinase p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors [corrected]Control of lymphopoiesis by p50csk, a regulatory protein tyrosine kinase.Lck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitionsThe biological activity of natural and mutant pTalpha allelesPeripheral expression of Jak3 is required to maintain T lymphocyte function.Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B-lymphocyte development.Functional dissection of the lck proximal promoter.Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor.Molecular basis for developmental changes in interleukin-2 gene inducibility.Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1.TCRalpha enhancer activation occurs via a conformational change of a pre-assembled nucleo-protein complex.c-Myb regulates the proliferation of immature thymocytes following beta-selection.Identification and characterization of a transcriptional regulator for the lck proximal promoter.T-lymphocyte development and function in gene-targeted mutant mice.p56lck signals for regulating thymocyte development can be distinguished by their dependency on Rho function.Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors.Lck plays a critical role in Ca(2+) mobilization and CD28 costimulation in mature primary T cells.Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene.
P2860
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P2860
Delayed thymocyte development induced by augmented expression of p56lck.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
@zh-cn
1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
@yue
1991年學術文章
@zh
1991年學術文章
@zh-hant
name
Delayed thymocyte development induced by augmented expression of p56lck.
@ast
Delayed thymocyte development induced by augmented expression of p56lck.
@en
type
label
Delayed thymocyte development induced by augmented expression of p56lck.
@ast
Delayed thymocyte development induced by augmented expression of p56lck.
@en
prefLabel
Delayed thymocyte development induced by augmented expression of p56lck.
@ast
Delayed thymocyte development induced by augmented expression of p56lck.
@en
P2093
P2860
P356
P1476
Delayed thymocyte development induced by augmented expression of p56lck.
@en
P2093
K A Forbush
K M Abraham
R M Perlmutter
P2860
P304
P356
10.1084/JEM.173.6.1421
P407
P577
1991-06-01T00:00:00Z