Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases.
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Structure and Protein-Protein Interactions of Human UDP-GlucuronosyltransferasesApplication of a physiologically based pharmacokinetic model to assess propofol hepatic and renal glucuronidation in isolation: utility of in vitro and in vivo data.Identification and characterization of human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of bergenin.Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system.Drug-botanical interactions: a review of the laboratory, animal, and human data for 8 common botanicals.The kinetic basis for age-associated changes in quercetin and genistein glucuronidation by rat liver microsomes.A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidationIdentification of diet-derived constituents as potent inhibitors of intestinal glucuronidation.Evaluation of metabolism-mediated herb-drug interactions.Enantiomer selective glucuronidation of the non-steroidal pure anti-androgen bicalutamide by human liver and kidney: role of the human UDP-glucuronosyltransferase (UGT)1A9 enzymeCorrelation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors.Diabetes mellitus reduces activity of human UDP-glucuronosyltransferase 2B7 in liver and kidney leading to decreased formation of mycophenolic acid acyl-glucuronide metabolite.The development of UDP-glucuronosyltransferases 1A1 and 1A6 in the pediatric liverUGT genomic diversity: beyond gene duplication.An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes.Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities.Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse BrainEvaluation of 3,3',4'-trihydroxyflavone and 3,6,4'-trihydroxyflavone (4'-O-glucuronidation) as the in vitro functional markers for hepatic UGT1A1.Accurate prediction of glucuronidation of structurally diverse phenolics by human UGT1A9 using combined experimental and in silico approaches.Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10Intestinal UGTs as potential modifiers of pharmacokinetics and biological responses to drugs and xenobiotics.Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction.Prevalence of UGT1A9 and UGT2B7 nonsynonymous single nucleotide polymorphisms in West African, Papua New Guinean, and North American populations.Phytochemical regulation of UDP-glucuronosyltransferases: implications for cancer prevention.Soy isoflavone metabolism in cats compared with other species: urinary metabolite concentrations and glucuronidation by liver microsomesHigh-throughput screening technologies for drug glucuronidation profiling.Effect of the beta-glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP-glucuronosyltransferases.Targeted precise quantification of 12 human recombinant uridine-diphosphate glucuronosyl transferase 1A and 2B isoforms using nano-ultra-high-performance liquid chromatography/tandem mass spectrometry with selected reaction monitoringEvidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion.UDP-glucuronosyltransferases (UGTs) in neuro-olfactory tissues: expression, regulation, and function.From known knowns to known unknowns: predicting in vivo drug metabolites.N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases.Understanding substrate selectivity of human UDP-glucuronosyltransferases through QSAR modeling and analysis of homologous enzymes.Gender-dependent differences in uridine 5'-diphospho-glucuronosyltransferase have implications in metabolism and clearance of xenobiotics.Transcriptional regulation of human UDP-glucuronosyltransferase genes.Posttranscriptional regulation of uridine diphosphate glucuronosyltransferases.Inhibitory Effects of Selected Antituberculosis Drugs on Common Human Hepatic Cytochrome P450 and UDP-glucuronosyltransferase Enzymes.Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-an Industry Perspective.Expression and inducibility of UDP-glucuronosyltransferase 1As in MCF-7 human breast carcinoma cells.In Vitro Inhibition of Human UDP-Glucuronosyl-Transferase (UGT) Isoforms by Astaxanthin, β-Cryptoxanthin, Canthaxanthin, Lutein, and Zeaxanthin: Prediction of in Vivo Dietary Supplement-Drug Interactions.
P2860
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P2860
Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Isoform-selective probe substr ...... UDP-glucuronosyltransferases.
@ast
Isoform-selective probe substr ...... UDP-glucuronosyltransferases.
@en
type
label
Isoform-selective probe substr ...... UDP-glucuronosyltransferases.
@ast
Isoform-selective probe substr ...... UDP-glucuronosyltransferases.
@en
prefLabel
Isoform-selective probe substr ...... UDP-glucuronosyltransferases.
@ast
Isoform-selective probe substr ...... UDP-glucuronosyltransferases.
@en
P1476
Isoform-selective probe substr ...... UDP-glucuronosyltransferases.
@en
P2093
Michael H Court
P304
P356
10.1016/S0076-6879(05)00007-8
P407
P577
2005-01-01T00:00:00Z