A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys.
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Immunoglobulin domain interface exchange as a platform technology for the generation of Fc heterodimers and bispecific antibodies.Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds.A Review of Obinutuzumab (GA101), a Novel Type II Anti-CD20 Monoclonal Antibody, for the Treatment of Patients with B-Cell Malignancies.Chemically Programmed Bispecific Antibodies in Diabody Format.An Update on the Use of Immunotherapy in the Treatment of Lymphoma.The use of CrossMAb technology for the generation of bi- and multispecific antibodies.Acute lymphoblastic leukemia: a comprehensive review and 2017 updateCurrent progress in innovative engineered antibodies.CEA TCB: A novel head-to-tail 2:1 T cell bispecific antibody for treatment of CEA-positive solid tumorsIncreased Potency of a Bi-specific TL1A-ADAM17 (TACE) Inhibitor by Cell Surface Targeting.A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1.The making of bispecific antibodiesTherapeutic Antibodies: What Have We Learnt from Targeting CD20 and Where Are We Going?Development of purification processes for fully human bispecific antibodies based upon modification of protein A binding avidity.Recombinant Antibodies to Arm Cytotoxic Lymphocytes in Cancer Immunotherapy.Rapid Purification of Human Bispecific Antibodies via Selective Modulation of Protein A Binding.T cell engaging bispecific antibody (T-BsAb): From technology to therapeutics.Redirecting T cells to hematological malignancies with bispecific antibodies.Generation of human bispecific common light chain antibodies by combining animal immunization and yeast display.Development of a novel affinity chromatography resin for platform purification of bispecific antibodies with modified protein a binding avidity.A Preclinical Population Pharmacokinetic Model for Anti-CD20/CD3 T-Cell-Dependent Bispecific Antibodies.Productive common light chain libraries yield diverse panels of high affinity bispecific antibodies.Modulation of protein A binding allows single-step purification of mouse bispecific antibodies that retain FcRn binding.A CD19/CD3 bispecific antibody for effective immunotherapy of chronic lymphocytic leukemia in the ibrutinib era.Expanding the Boundaries of Biotherapeutics with Bispecific Antibodies
P2860
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P2860
A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys.
description
2015 nî lūn-bûn
@nan
2015年の論文
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2015年学术文章
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2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
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2015年學術文章
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name
A novel, native-format bispeci ...... models and cynomolgus monkeys.
@ast
A novel, native-format bispeci ...... models and cynomolgus monkeys.
@en
type
label
A novel, native-format bispeci ...... models and cynomolgus monkeys.
@ast
A novel, native-format bispeci ...... models and cynomolgus monkeys.
@en
prefLabel
A novel, native-format bispeci ...... models and cynomolgus monkeys.
@ast
A novel, native-format bispeci ...... models and cynomolgus monkeys.
@en
P2093
P2860
P356
P1433
P1476
A novel, native-format bispeci ...... models and cynomolgus monkeys.
@en
P2093
Adelekan Oyejide
Andrew D Tustian
Bindu Varghese
Douglas MacDonald
Eric J Smith
Gavin Thurston
George D Yancopoulos
Jayanthi Menon
Jennifer Principio
Jessica R Kirshner
P2860
P2888
P356
10.1038/SREP17943
P407
P577
2015-12-11T00:00:00Z