Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes
about
Functional heterogeneity of marginal zone B cells revealed by their ability to generate both early antibody-forming cells and germinal centers with hypermutation and memory in response to a T-dependent antigenGerminal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cellsProduction of human monoclonal antibodies in SCID mouse.Neonatal immunity and somatic mutation.Immunologic aspects of monoclonal B-cell lymphocytosisImmunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair.Paratope diversity in the human antibody response to Bacillus anthracis protective antigen.DNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation.Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation.Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice.T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion.Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challengeAppearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humansHuman B cells accumulate immunoglobulin V gene somatic mutations in a cell contact-dependent manner in cultures supported by activated T cells but not in cultures supported by CD40 ligand.Lymphotoxin-alpha-deficient and TNF receptor-I-deficient mice define developmental and functional characteristics of germinal centers.Age-related changes in antibody repertoire: contribution from T cells.Immunosenescence and germinal center reaction.Adaptive immune response to model antigens is impaired in murine leukocyte-adhesion deficiency-1 revealing elevated activation thresholds in vivoGerminal centers in human lymph nodes contain reactivated memory B cells.IgD+IgM- B cells mount immune responses that exhibit altered antibody repertoire.Expansion and Sub-Classification of T Cell-Dependent Antibody Responses to Encompass the Role of Innate-Like T Cells in Antibody Responses
P2860
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P2860
Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Facultative role of germinal c ...... diversification of IgVH genes
@ast
Facultative role of germinal c ...... diversification of IgVH genes
@en
type
label
Facultative role of germinal c ...... diversification of IgVH genes
@ast
Facultative role of germinal c ...... diversification of IgVH genes
@en
prefLabel
Facultative role of germinal c ...... diversification of IgVH genes
@ast
Facultative role of germinal c ...... diversification of IgVH genes
@en
P2093
P2860
P356
P1476
Facultative role of germinal c ...... diversification of IgVH genes
@en
P2093
P2860
P304
P356
10.1084/JEM.181.4.1319
P407
P577
1995-04-01T00:00:00Z