Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells
about
Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosisRORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cellsThe aetiology of idiopathic Parkinson's diseaseGasp, a Grb2-associating protein, is critical for positive selection of thymocytesThe nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner earSeveral different cell surface molecules control negative selection of medullary thymocytesFunctional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosisResistance of Foxp3+ regulatory T cells to Nur77-induced apoptosis promotes allograft survival.Genetic control of programmed cell death during animal development.Application of a Fas ligand encoding a recombinant adenovirus vector for prolongation of transgene expression.Ca(2+)-dependent gene expression mediated by MEF2 transcription factors.T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunityTargeting Nur77 translocation.Protein kinase C regulates mitochondrial targeting of Nur77 and its family member Nor-1 in thymocytes undergoing apoptosis.The role of NR4A transcription factors in memory formationCostimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4(+)CD8(+) thymocytes.CD4⁺CD25⁺Foxp3⁺ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletionNur77 deficiency leads to systemic inflammation in elderly mice.Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletionThe transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytes.Cellular and genetic mechanisms of self tolerance and autoimmunity.Examination of thymic positive and negative selection by flow cytometry.The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells.The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity.During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain.Antidiabetogenic MHC class II promotes the differentiation of MHC-promiscuous autoreactive T cells into FOXP3+ regulatory T cells.Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines.Apoptosis in the development of the immune system.What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain.ERK and cell death: ERK location and T cell selection.Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77.Strength of TCR signal from self-peptide modulates autoreactive thymocyte deletion and Foxp3(+) Treg-cell formation.Dnmt3a regulates T-cell development and suppresses T-ALL transformation.Antenatal endogenous and exogenous glucocorticoids and their impact on immune ontogeny and long-term immunity.6-Mercaptopurine, an activator of Nur77, enhances transcriptional activity of HIF-1alpha resulting in new vessel formation.Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells.Nur77 transcription activity correlates with its apoptotic function in vivo.NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis.Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes.MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling.
P2860
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P2860
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells
@ast
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells
@en
type
label
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells
@ast
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells
@en
prefLabel
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells
@ast
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells
@en
P2093
P2860
P356
P1476
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells
@en
P2093
H Bluethmann
J D Mountz
P2860
P304
P356
10.1084/JEM.183.4.1879
P407
P577
1996-04-01T00:00:00Z