Modulation of immunoglobulin (Ig)E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG. - Wikidata - awgldk - TriplyDB

Modulation of immunoglobulin (Ig)E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG.

Modulation of immunoglobulin (Ig)E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG.

http://www.wikidata.org/entity/Q36369947

about

An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions Medical immunology: a new journal for a new subspecialty.Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus CD84 negatively regulates IgE high-affinity receptor signaling in human mast cells Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap.Insufficient phosphorylation prevents fc gamma RIIB from recruiting the SH2 domain-containing protein-tyrosine phosphatase SHP-1.FcgammaRIIb inhibits allergic lung inflammation in a murine model of allergic asthma Signalling through the high-affinity IgE receptor Fc epsilonRI.Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis.Suppression of IgE B cells and IgE binding to Fc(epsilon)RI by gene therapy with single-chain anti-IgE.What are the most promising strategies for the therapeutic immunomodulation of allergic diseases?Regulation of hematopoietic cell function by inhibitory immunoglobulin G receptors and their inositol lipid phosphatase effectors.IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking."Auto-anti-IgE": naturally occurring IgG anti-IgE antibodies may inhibit allergen-induced basophil activation.Differential roles for the IL-9/IL-9 receptor alpha-chain pathway in systemic and oral antigen-induced anaphylaxis.Oral immunotherapy induces IgG antibodies that act through FcγRIIb to suppress IgE-mediated hypersensitivity.Roles of Fc receptors in autoimmunity.Impairment of the antibody-dependent phagocytic function of PMNs through regulation of the FcγRs expression after porcine reproductive and respiratory syndrome virus infection.Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23 Functional Fcgamma receptor polymorphisms are associated with human allergy.The role of FcgammaRIIa as an inflammatory mediator in rheumatoid arthritis and systemic lupus erythematosus.Human FcγRIIA induces anaphylactic and allergic reactions.Intestinal mast cell levels control severity of oral antigen-induced anaphylaxis in mice Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer.Regulation of mast cell responses in health and disease.Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation Fc gamma RIIa, not Fc gamma RIIb, is constitutively and functionally expressed on skin-derived human mast cells.Markedly different pathogenicity of four immunoglobulin G isotype-switch variants of an antierythrocyte autoantibody is based on their capacity to interact in vivo with the low-affinity Fcgamma receptor III.Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice.Antigen-independent induction of histamine synthesis by immunoglobulin E in mouse bone marrow-derived mast cells.Dexamethasone Induces FcγRIIb Expression in RBL-2H3 Cells Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis FcgammaRIII is protective against Pseudomonas aeruginosa pneumonia Potential effector and immunoregulatory functions of mast cells in mucosal immunity.Quorum sensing contributes to activated IgM-secreting B cell homeostasis.Unique populations of lung mast cells are required for antigen-mediated bronchoconstriction.Interrogation of sphingosine-1-phosphate receptor 2 function in vivo reveals a prominent role in the recovery from IgE and IgG-mediated anaphylaxis with minimal effect on its onset The mast cell IgG receptors and their roles in tissue inflammation.

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Modulation of immunoglobulin (Ig)E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG.

http://www.wikidata.org/entity/Q36369947

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1999 nî lūn-bûn

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Modulation of immunoglobulin ( ...... affinity Fc receptors for IgG.

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J V Ravetch

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M Fukumoto

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M Ono

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P2860

Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice

Active anaphylaxis in IgE-deficient mice

Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

Selected Aspects of Homeobox Gene Function during Mammalian Development.

Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice.

Identification of the low affinity receptor for immunoglobulin E on mouse mast cells and macrophages as Fc gamma RII and Fc gamma RIII.

The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation.

Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors

IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions.

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1573-1579

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