Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis
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Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic interventionPotential Antifungal Targets against a Candida Biofilm Based on an Enzyme in the Arachidonic Acid Cascade-A ReviewPhospholipases of mineralization competent cells and matrix vesicles: roles in physiological and pathological mineralizationsA novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis.Cytosolic phospholipase A2 regulates TNF-induced production of joint destructive effectors in synoviocytes.Cytosolic phospholipase A2α is critical for angiotensin II-induced hypertension and associated cardiovascular pathophysiology.Cytosolic phospholipase A(2)α protects against ischemia/reperfusion injury in the heart.Host cytosolic phospholipase A₂α contributes to group B Streptococcus penetration of the blood-brain barrier.The RNA-binding protein HuR stabilizes cytosolic phospholipase A2α mRNA under interleukin-1β treatment in non-small cell lung cancer A549 CellsCytosolic phospholipase A2 modulates TLR2 signaling in synoviocytesStudy of the role of cytosolic phospholipase A2 alpha in eicosanoid generation and thymocyte maturation in the thymusIdentifying a major locus that regulates spontaneous arthritis in IL-1ra-deficient mice and analysis of potential candidatesCytosolic phospholipase A₂: physiological function and role in disease.cPLA(2)α gene activation by IL-1β is dependent on an upstream kinase pathway, enzymatic activation and downstream 15-lipoxygenase activity: a positive feedback loopProstacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis.Rheumatic diseases: the effects of inflammation on bone.An essential role of cytosolic phospholipase A2alpha in prostaglandin E2-mediated bone resorption associated with inflammationCytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis.Roles of cPLA2alpha and arachidonic acid in cancerCytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidaseCa2+ activation of the cPLA2 C2 domain: ordered binding of two Ca2+ ions with positive cooperativity.Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinaseMembrane and inhibitor interactions of intracellular phospholipases A2.Regulation of Wnt/beta-catenin pathway by cPLA2alpha and PPARdeltaA distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss.Low molecular weight hyaluronan activates cytosolic phospholipase A2α and eicosanoid production in monocytes and macrophages.HO-1 induction by CO-RM2 attenuates TNF-α-induced cytosolic phospholipase A2 expression via inhibition of PKCα-dependent NADPH oxidase/ROS and NF-κB.Targeting monocytes/macrophages in the treatment of rheumatoid arthritis.Persisting eicosanoid pathways in rheumatic diseases.Molecular characterisation of group IVA (cytosolic) phospholipase A2 in murine osteoblastic MC3T3-E1 cells.Interleukin-32 positively regulates radiation-induced vascular inflammation.Activation of cytosolic phospholipase A2alpha through nitric oxide-induced S-nitrosylation. Involvement of inducible nitric-oxide synthase and cyclooxygenase-2.Membrane-docking loops of the cPLA2 C2 domain: detailed structural analysis of the protein-membrane interface via site-directed spin-labeling.Cytosolic phospholipase A2 Group IValpha but not secreted phospholipase A2 Group IIA, V, or X induces interleukin-8 and cyclooxygenase-2 gene and protein expression through peroxisome proliferator-activated receptors gamma 1 and 2 in human lung cellCysteinyl leukotrienes as novel host factors facilitating Cryptococcus neoformans penetration into the brain.Mechanism of glutamine inhibition of cytosolic phospholipase a2 (cPLA2 ): Evidence of physical interaction between glutamine-Induced mitogen-activated protein kinase phosphatase-1 and cPLA2.Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effectTLR-4 mediated group IVA phospholipase A(2) activation is phosphatidic acid phosphohydrolase 1 and protein kinase C dependent.Targeting leukotriene B4 in inflammation.Genomic dissection and prioritizing of candidate genes of QTL for regulating spontaneous arthritis on chromosome 1 in mice deficient for interleukin-1 receptor antagonist.
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P2860
Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
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2003年學術文章
@zh-hant
name
Cytosolic phospholipase A2alph ...... to collagen-induced arthritis
@ast
Cytosolic phospholipase A2alph ...... to collagen-induced arthritis
@en
type
label
Cytosolic phospholipase A2alph ...... to collagen-induced arthritis
@ast
Cytosolic phospholipase A2alph ...... to collagen-induced arthritis
@en
prefLabel
Cytosolic phospholipase A2alph ...... to collagen-induced arthritis
@ast
Cytosolic phospholipase A2alph ...... to collagen-induced arthritis
@en
P2093
P2860
P356
P1476
Cytosolic phospholipase A2alph ...... to collagen-induced arthritis
@en
P2093
Cheryl L Nickerson-Nutter
James D Clark
Kazuhiko Kume
Linhong Sun
Martin Hegen
Mary E Goad
Naonori Uozumi
Takao Shimizu
P2860
P304
P356
10.1084/JEM.20030016
P407
P577
2003-05-12T00:00:00Z