The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways
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Bench-to-bedside review: functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsisThe multifaceted role of the renal microvasculature during acute kidney injuryPAMPs and DAMPs as triggers for DICFrom neutrophil extracellular traps release to thrombosis: an overshooting host-defense mechanism?Human endosialin (tumor endothelial marker 1) is abundantly expressed in highly malignant and invasive brain tumorsThe pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansionEmerging therapeutic targets of sepsis-associated acute kidney injury.Soluble thrombomodulin protects ischemic kidneysAnchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation.Specificities of platelet autoantibodies and platelet activation in lupus anticoagulant patients: a relation to their history of thromboembolic disease.Thrombomodulin mutations in atypical hemolytic-uremic syndrome.Controlling coagulation dysregulation in xenotransplantation.The efficacy of recombinant human soluble thrombomodulin for the treatment of shiga toxin-associated hemolytic uremic syndrome model mice.Monocytic thrombomodulin promotes cell adhesion through interacting with its ligand, Lewisy.G-protein coupled receptor 15 mediates angiogenesis and cytoprotective function of thrombomodulin.The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism.CD248 facilitates tumor growth via its cytoplasmic domain.Endothelial cell markers reflecting endothelial cell dysfunction in patients with mixed connective tissue disease.Solulin reduces infarct volume and regulates gene-expression in transient middle cerebral artery occlusion in ratsThrombomodulin as an intravascular safeguard against inflammatory and thrombotic diseases.Regulation of endothelial cell inflammation and lung polymorphonuclear lymphocyte infiltration by transglutaminase 2.Effects of a thrombomodulin-derived peptide on monocyte adhesion and intercellular adhesion molecule-1 expression in lipopolysaccharide-induced endothelial cells.Role of tissue factor in Mycobacterium tuberculosis-induced inflammation and disease pathogenesis.Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltrationNew mechanisms for vascular control of inflammation mediated by natural anticoagulant proteins.Differential gene expression in thrombomodulin (TM; CD141)(+) and TM(-) dendritic cell subsetsThrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanism.Inflammation and thrombosis.Thrombomodulin.Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain.Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis.Interactions between coagulation and inflammation.Regulation of inflammatory responses by activated protein C: the molecular mechanism(s) and therapeutic implications.Extraembryonic expression of EPCR is essential for embryonic viability.Soluble thrombomodulin reduces inflammation and prevents microalbuminuria induced by chronic endothelial activation in transgenic miceThe role of thrombomodulin lectin-like domain in inflammationNEU1 and NEU3 sialidase activity expressed in human lung microvascular endothelia: NEU1 restrains endothelial cell migration, whereas NEU3 does notPathogenic and Diagnostic Potential of BLCA-1 and BLCA-4 Nuclear Proteins in Urothelial Cell Carcinoma of Human BladderActivated Protein C Ameliorates Renal Ischemia-Reperfusion Injury by Restricting Y-Box Binding Protein-1 UbiquitinationCoagulopathy and the role of recombinant human activated protein C in sepsis and following polytrauma.
P2860
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P2860
The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
The lectin-like domain of thro ...... ivated protein kinase pathways
@ast
The lectin-like domain of thro ...... ivated protein kinase pathways
@en
type
label
The lectin-like domain of thro ...... ivated protein kinase pathways
@ast
The lectin-like domain of thro ...... ivated protein kinase pathways
@en
prefLabel
The lectin-like domain of thro ...... ivated protein kinase pathways
@ast
The lectin-like domain of thro ...... ivated protein kinase pathways
@en
P2093
P2860
P50
P356
P1476
The lectin-like domain of thro ...... ivated protein kinase pathways
@en
P2093
Astrid De Vriese
Désiré Collen
Gregor Theilmeier
Hartmut Weiler
Hugo Van Aken
Jean-Marc Herbert
Jeffrey I Weitz
Kerstin Jurk
Marlies Van de Wouwer
Saskia Pollefeyt
P2860
P304
P356
10.1084/JEM.20020077
P407
P577
2002-09-01T00:00:00Z