Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. - Wikidata - awgldk - TriplyDB

Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node.

Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node.

http://www.wikidata.org/entity/Q36371218

about

Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin Role of Dendritic Cells in the Induction of Lymphocyte Tolerance Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs Dendritic cells: arbiters of immunity and immunological tolerance Targeting dendritic cell function during systemic autoimmunity to restore tolerance The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells Murine melanoma-infiltrating dendritic cells are defective in antigen presenting function regardless of the presence of CD4CD25 regulatory T cells H2 control of natural T regulatory cell frequency in the lymph node correlates with susceptibility to day 3 thymectomy-induced autoimmune disease Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation.Cutting edge: normal regional lymph node enrichment of antigen-specific regulatory T cells with autoimmune disease-suppressive capacity.Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node.The role of physiological self-antigen in the acquisition and maintenance of regulatory T-cell function.Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.Induction of auto-reactive regulatory T cells by stimulation with immature autologous dendritic cells.Blood glucose levels regulate pancreatic beta-cell proliferation during experimentally-induced and spontaneous autoimmune diabetes in mice.Immune responses to Helicobacter pylori infection.Steady state dendritic cells present parenchymal self-antigen and contribute to, but are not essential for, tolerization of naive and Th1 effector CD4 cells.Dendritic cells program non-immunogenic prostate-specific T cell responses beginning at early stages of prostate tumorigenesis.Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation.Dendritic cell-regulatory T-cell interactions control self-directed immunity.Apoptotic cell-based therapies against transplant rejection: role of recipient's dendritic cells.The use of mouse models to better understand mechanisms of autoimmunity and tolerance IL-10-dependent partial refractoriness to Toll-like receptor stimulation modulates gut mucosal dendritic cell function.Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4.Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo.Campylobacter jejuni induces maturation and cytokine production in human dendritic cells.Early immunisation with dendritic cells after allogeneic bone marrow transplantation elicits graft vs tumour reactivity.Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues.Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A.Improved local and systemic anti-tumor efficacy for irreversible electroporation in immunocompetent versus immunodeficient mice.Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming.Dendritic cells, T cell tolerance and therapy of adverse immune reactions.Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria.Some interfaces of dendritic cell biology.Airway dendritic cells: co-ordinators of immunological homeostasis and immunity in the respiratory tract.Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction.Tregs and infections: on the potential value of modifying their function.Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells.

P2860

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P2860

Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node.

http://www.wikidata.org/entity/Q36371218

description

2002 nî lūn-bûn

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Clemens Scheinecker

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Ethan M Shevach

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Rebecca McHugh

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Ronald N Germain

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P2860

Dendritic cells and the control of immunity

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha

Expression of relB is required for the development of thymic medulla and dendritic cells

Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo

Production, specificity, and functionality of monoclonal antibodies to specific peptide-major histocompatibility complex class II complexes formed by processing of exogenous protein.

Natural adjuvants: endogenous activators of dendritic cells.

Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance.

Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo.

The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis.

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1079-1090

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10.1084/JEM.20020991

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8

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196

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12391019

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