High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein - Wikidata - awgldk - TriplyDB

High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein

High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein

http://www.wikidata.org/entity/Q36371517

about

Hepatitis B Virus Immunopathology, Model Systems, and Current Therapies Allosteric conformational changes of human HBV core protein transform its assembly.Distinct Viral Lineages from Fish and Amphibians Reveal the Complex Evolutionary History of Hepadnaviruses.Hepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine Pocket New therapies for chronic hepatitis B.Influences on viral replication and sensitivity to GLS4, a HAP compound, of naturally occurring T109/V124 mutations in hepatitis B virus core protein.Hepatitis B Virus Capsid Assembly Modulators, but Not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants Future anti-HBV strategies.The current status and future directions of hepatitis B antiviral drug discovery.Discovery and Mechanistic Study of Benzamide Derivatives That Modulate Hepatitis B Virus Capsid Assembly.Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms Design, Synthesis, and Evaluation of Tetrahydropyrrolo[1,2-c]pyrimidines as Capsid Assembly Inhibitors for HBV Treatment.HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways.Hepatitis B cure: From discovery to regulatory approval.The Structural Biology of Hepatitis B Virus: Form and Function.Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids.Preclinical profile of AB-423, an inhibitor of Hepatitis B virus pgRNA encapsidation.The Heteroaryldihydropyrimidine Bay 38-7690 Induces Hepatitis B Virus Core Protein Aggregates Associated with Promyelocytic Leukemia Nuclear Bodies in Infected Cells.Hepatitis B virus core protein dephosphorylation occurs during pregenomic RNA encapsidation.Structures of Hepatitis B Virus Core- and e-Antigen Immune Complexes Suggest Multi-point Inhibition Assembly Properties of Hepatitis B Virus Core Protein Mutants Correlate with Their Resistance to Assembly-Directed Antivirals

P2860

Q33559657-3A7A095E-E5A8-49A7-BB8D-54B0ACA8900E Q33684415-7B77E418-2040-4B91-9662-FFDE2FB3CB54 Q34531745-C8510447-578E-4E41-AE56-11F0D8247950 Q36736446-FB38387E-2493-485A-9338-476BC3AA02F4 Q38725759-28A1AC10-D39B-48BF-A849-CB21E2845D48 Q38731499-EC0DBE6D-516C-4A10-A4E4-6C760FBEA2FD Q38755680-179EB6AA-834E-47C7-95D6-22B3F124E78D Q38774853-63D3C4E1-4FD0-46AC-995D-6B2C1F6CC6B9 Q38802098-8466149B-F4B3-4598-9EBB-5DB47B8C263C Q40178518-4C185D6E-DE9E-41A1-B7A1-94B9BCA04ECF Q40330419-3679648E-B4C6-4F3F-9FDB-11FD808F8A00 Q41930281-A3FDD893-4120-4D2D-91BF-7A352077E1D3 Q41930702-B110ACE4-288F-4F4B-BC2C-43437748FD70 Q41952398-D6ACCCD6-D3A5-44A5-82F4-0FB464A9720C Q42048428-64CEF5F6-0AD9-480E-925B-F398AD995D86 Q47548307-BB39BC62-30F1-4DB5-B166-145F7F1F8711 Q51738220-31E76686-238F-4272-B7BB-4EB3529EB00E Q52579709-10CE748A-6B4D-4D6F-9FCC-C33D02E1D7BA Q52579748-EEFFE1D7-AEAF-4875-9FA6-5ADE5B07BFDC Q57050752-EA0DF897-D613-400C-AB46-C08E1B82C7A1 Q57445698-C7F79883-C92C-4069-B023-36CE93674B68

P2860

High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein

http://www.wikidata.org/entity/Q36371517

description

2015 nî lūn-bûn

@nan

2015年の論文

@ja

2015年学术文章

@wuu

2015年学术文章

@zh-cn

2015年学术文章

@zh-hans

2015年学术文章

@zh-my

2015年学术文章

@zh-sg

2015年學術文章

@yue

2015年學術文章

@zh

2015年學術文章

@zh-hant

name

High-resolution crystal struct ...... ound to the viral core protein

@ast

High-resolution crystal struct ...... ound to the viral core protein

@en

type

label

High-resolution crystal struct ...... ound to the viral core protein

@ast

High-resolution crystal struct ...... ound to the viral core protein

@en

prefLabel

High-resolution crystal struct ...... ound to the viral core protein

@ast

High-resolution crystal struct ...... ound to the viral core protein

@en

P1433

Q36371517-35086BD3-ECA0-448D-A268-D3B4BEAEECFE

P1476

Q36371517-AD53776E-D33C-408A-8C67-B8E99CA14ABC

P2093

Q36371517-039C8989-4D4E-4FD3-AFD1-28047AC426F5

Q36371517-0CC35405-8C10-4B86-9C7A-0C1C9FE59275

Q36371517-33AE14A2-7F18-40A4-B245-4279A9C7E75F

Q36371517-67957EA0-BF48-47E7-B38F-182C24C187EB

Q36371517-76DF11DD-5235-4C5C-8969-2207185D0150

Q36371517-7F423514-D65D-487A-A22D-7CBF52ABC9E7

Q36371517-843F0A80-85B2-4581-B137-5919432F9E87

Q36371517-87CEAAE2-56DC-49B8-9B3D-3FA8FB7E0D29

Q36371517-8BEF5AB2-A246-49BF-BDC2-7403AD6FDD25

Q36371517-8DAD2FCD-5930-4CD2-8133-1761B7656119

P2860

Q36371517-074BB310-0217-47DA-926B-14BBF527141C

Q36371517-1C1A4DB4-4B57-4118-B469-6E7214D066E4

Q36371517-1F3CCBEE-E367-4054-A9EA-86B60E5D8907

Q36371517-273A4528-AA3C-46A4-9EDC-BD3241277CB6

Q36371517-3CA22D1C-8BEB-40A2-8EE8-32B0668F4FD7

Q36371517-44D16CC3-052C-49C3-9FA2-8FAD4CDD39DA

Q36371517-519638E3-B6D8-4975-8EC7-9139EDE396C2

Q36371517-51C62B31-65C3-46E7-B23D-0859025508C5

Q36371517-525469E0-0E03-4F72-AAB6-79C656C49ED8

Q36371517-5CA9DBF9-376C-4207-9BF0-F3B0A86078A4

P304

Q36371517-5D799D87-706A-40B7-BEA6-3C8CE8F84AEA

P31

Q36371517-C8DFEC75-4556-445F-A030-C63437B0811F

P356

Q36371517-C9B0F251-329A-49BA-9412-3D6E2083126E

P407

Q36371517-7DEED191-596D-46E3-9C15-DB0A0D05E512

P433

Q36371517-1E9867D3-4DA9-48BF-8721-3D1F401CB71D

P478

Q36371517-B045F835-8F43-4619-9AD5-761301D02214

P577

Q36371517-751AFD52-CCC0-4564-AE20-537222E05644

P5875

Q36371517-2AC84B13-A4CF-401B-AB7B-2715E62C3FDB

P698

Q36371517-4487849C-8721-4349-8C0E-75E686F5A61E

P921

Q36371517-6D775361-C1E0-4BDC-B579-BE526F3B0CAD

P932

Q36371517-19D2D7FE-DA59-447A-9A0A-6346D5A54C43

P356

PNAS.1513803112

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

High-resolution crystal struct ...... ound to the viral core protein

@en

P2093

Andrey Efimov

http://www.w3.org/2001/XMLSchema#string

Angela M Lam

http://www.w3.org/2001/XMLSchema#string

Christine Espiritu

http://www.w3.org/2001/XMLSchema#string

Christine Lukacs

http://www.w3.org/2001/XMLSchema#string

George Hartman

http://www.w3.org/2001/XMLSchema#string

Guochun Liao

http://www.w3.org/2001/XMLSchema#string

Jan Abendroth

http://www.w3.org/2001/XMLSchema#string

Kateri Atkins

http://www.w3.org/2001/XMLSchema#string

Klaus Klumpp

http://www.w3.org/2001/XMLSchema#string

Osvaldo A Flores

http://www.w3.org/2001/XMLSchema#string

P2860

The crystal structure of the human hepatitis B virus capsid

Conformational Changes in the Hepatitis B Virus Core Protein Are Consistent with a Role for Allostery in Virus Assembly

Thermodynamic origins of protein folding, allostery, and capsid formation in the human hepatitis B virus core protein

Assembly-Directed Antivirals Differentially Bind Quasiequivalent Pockets to Modify Hepatitis B Virus Capsid Tertiary and Quaternary Structure

Antiviral activity of Bay 41-4109 on hepatitis B virus in humanized Alb-uPA/SCID mice

Native hepatitis B virions and capsids visualized by electron cryomicroscopy.

Sulfamoylbenzamide derivatives inhibit the assembly of hepatitis B virus nucleocapsids.

2-amino-N-(2,6-dichloropyridin-3-yl)acetamide derivatives as a novel class of HBV capsid assembly inhibitor.

In vitro screening for molecules that affect virus capsid assembly (and other protein association reactions)

Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly.

P304

15196-15201

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.1513803112

http://www.w3.org/2001/XMLSchema#string

P407

P433

49

http://www.w3.org/2001/XMLSchema#string

P478

112

http://www.w3.org/2001/XMLSchema#string

P577

2015-11-23T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

284518160

http://www.w3.org/2001/XMLSchema#string

P698

26598693

http://www.w3.org/2001/XMLSchema#string

P921

protein structure

P932

4679053

http://www.w3.org/2001/XMLSchema#string