Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor.
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Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptidesEmerging Therapies for OsteoporosisPTH receptor-1 signalling-mechanistic insights and therapeutic prospectsParathyroid hormone and parathyroid hormone-related protein analogs as therapies for osteoporosisStructural Basis for Antibody Discrimination between Two Hormones That Recognize the Parathyroid Hormone ReceptorAbaloparatideTransmembrane signal transduction by peptide hormones via family B G protein-coupled receptorsThe N- and C-terminal domains of parathyroid hormone-related protein affect differently the osteogenic and adipogenic potential of human mesenchymal stem cellsParathyroid hormone-related protein for the treatment of postmenopausal osteoporosis: defining the maximal tolerable dose.Lactation and bone turnover: a conundrum of marked bone loss in the setting of coupled bone turnoverProfile of Abaloparatide and Its Potential in the Treatment of Postmenopausal Osteoporosis.Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPaseSustained cyclic AMP production by parathyroid hormone receptor endocytosis.Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid hormone analogsInternational Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.Endosomal generation of cAMP in GPCR signaling.Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectivesA 7-day continuous infusion of PTH or PTHrP suppresses bone formation and uncouples bone turnover.Theme and variations on kinetics of GPCR activation/deactivation.Non-canonical signaling of the PTH receptorParathyroid hormone-related protein: an update.Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling.Noncanonical GPCR signaling arising from a PTH receptor-arrestin-Gβγ complexMolecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm.Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTHPTH Signaling and Epigenetic Control of Bone Remodeling.Eliminating phosphorylation sites of the parathyroid hormone receptor type 1 differentially affects stimulation of phospholipase C and receptor internalization.Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation.Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related proteinPTH and PTH antagonist induce different conformational changes in the PTHR1 receptor.Mechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells.PTH and PTHrP signaling in osteoblastsSix Weeks of Daily Abaloparatide Treatment Increased Vertebral and Femoral Bone Mineral Density, Microarchitecture and Strength in Ovariectomized Osteopenic RatsIdentification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism.Minireview: More than just a hammer: ligand "bias" and pharmaceutical discovery.From parathyroid hormone to cytosolic Ca2+ signals.Parathyroid Hormone-Related Protein Analogs as Osteoporosis Therapies.Parathyroid Hormone-Related Protein, Its Regulation of Cartilage and Bone Development, and Role in Treating Bone Diseases.GPCR Signaling and Trafficking: The Long and Short of It.Translating in vitro ligand bias into in vivo efficacy.
P2860
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P2860
Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Altered selectivity of parathy ...... ons of the PTH/PTHrP receptor.
@ast
Altered selectivity of parathy ...... ons of the PTH/PTHrP receptor.
@en
type
label
Altered selectivity of parathy ...... ons of the PTH/PTHrP receptor.
@ast
Altered selectivity of parathy ...... ons of the PTH/PTHrP receptor.
@en
prefLabel
Altered selectivity of parathy ...... ons of the PTH/PTHrP receptor.
@ast
Altered selectivity of parathy ...... ons of the PTH/PTHrP receptor.
@en
P2093
P2860
P356
P1476
Altered selectivity of parathy ...... ions of the PTH/PTHrP receptor
@en
P2093
John T Potts
Thomas Dean
Thomas J Gardella
P2860
P304
P356
10.1210/ME.2007-0274
P577
2007-09-13T00:00:00Z