Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands
about
Structure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 Å resolutionA novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres.Macrocyclic shape-persistency of cyclo[6]aramide results in enhanced multipoint recognition for the highly efficient template-directed synthesis of rotaxanes.High conductance values in π-folded molecular junctions.Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.Identification of novel quadruplex ligands from small molecule libraries by FRET-based high-throughput screening.Synthesis of Macrocyclic Hexaoxazole (6OTD) Dimers, Containing Guanidine and Amine Functionalized Side Chains, and an Evaluation of Their Telomeric G4 Stabilizing Properties."One ring to bind them all"-part I: the efficiency of the macrocyclic scaffold for g-quadruplex DNA recognition.Synthesis of bis-indole carboxamides as G-quadruplex stabilizing and inducing ligands.Advances in the molecular design of potential anticancer agents via targeting of human telomeric DNA.Targeting DNA G-quadruplexes with helical small molecules.Contrasting enantioselective DNA preference: chiral helical macrocyclic lanthanide complex binding to DNA.Molecular recognition of a carboxy pyridostatin toward G-quadruplex structures: Why does it prefer RNA?Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA.Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cellsA hitchhiker's guide to G-quadruplex ligands.Natural isoflavones regulate the quadruplex-duplex competition in human telomeric DNAG-quadruplex DNA bound by a synthetic ligand is highly dynamic.Human telomeric G-quadruplex: structures of DNA and RNA sequences.New Modalities for Challenging Targets in Drug Discovery.Affinity of the anthracycline antitumor drugs Doxorubicin and Sabarubicin for human telomeric G-quadruplex structures.The effects of molecular crowding on the structure and stability of g-quadruplexes with an abasic site.An overview of peptide and peptoid foldamers in medicinal chemistry.Computational Prediction and Rationalization, and Experimental Validation of Handedness Induction in Helical Aromatic Oligoamide Foldamers.Platinum(II) phenanthroimidazoles for targeting telomeric G-quadruplexes.Solution Observation of Dimerization and Helix Handedness Induction in a Human Carbonic Anhydrase-Helical Aromatic Amide Foldamer Complex.Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition.Controlled-folding of a small molecule modulates DNA G-quadruplex recognitionG-quadruplex recognition by bis-indole carboxamides.Diarylethynyl amides that recognize the parallel conformation of genomic promoter DNA G-quadruplexesShape-persistent H-bonded macrocyclic aromatic pentamers.Identifying G-quadruplex-binding ligands using DNA-functionalized gold nanoparticles.Size-dependent patterned recognition and extraction of metal ions by a macrocyclic aromatic pyridone pentamer.Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State.Asymmetric distyrylpyridinium dyes as red-emitting fluorescent probes for quadruplex DNA.Enantiomers of tetrahedral metal-organic cages: a new class of highly efficient G-quadruplex ligands with potential anticancer activities.Computation-guided improved one-pot synthesis of macrocyclic cation-binding aromatic pyridone pentamers.Methyl substitution regulates the enantioselectivity of supramolecular complex binding to human telomeric G-quadruplex DNA.Enantioselective sulfoxidation reaction catalyzed by a G-quadruplex DNA metalloenzyme.Chiral metallo-supramolecular complexes selectively induce human telomeric G-quadruplex formation under salt-deficient conditions.
P2860
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P2860
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands
@ast
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands
@en
type
label
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands
@ast
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands
@en
prefLabel
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands
@ast
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands
@en
P2093
P2860
P356
P1476
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands
@en
P2093
Elizabeth R Gillies
Frédéric Godde
Kazuo Shin-Ya
Pravin S Shirude
Shankar Balasubramanian
Sylvain Ladame
P2860
P304
11890-11891
P356
10.1021/JA073775H
P407
P577
2007-09-11T00:00:00Z