Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands - Wikidata - awgldk - TriplyDB

Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands

Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands

http://www.wikidata.org/entity/Q36376134

about

Structure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 Å resolution A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres.Macrocyclic shape-persistency of cyclo[6]aramide results in enhanced multipoint recognition for the highly efficient template-directed synthesis of rotaxanes.High conductance values in π-folded molecular junctions.Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.Identification of novel quadruplex ligands from small molecule libraries by FRET-based high-throughput screening.Synthesis of Macrocyclic Hexaoxazole (6OTD) Dimers, Containing Guanidine and Amine Functionalized Side Chains, and an Evaluation of Their Telomeric G4 Stabilizing Properties."One ring to bind them all"-part I: the efficiency of the macrocyclic scaffold for g-quadruplex DNA recognition.Synthesis of bis-indole carboxamides as G-quadruplex stabilizing and inducing ligands.Advances in the molecular design of potential anticancer agents via targeting of human telomeric DNA.Targeting DNA G-quadruplexes with helical small molecules.Contrasting enantioselective DNA preference: chiral helical macrocyclic lanthanide complex binding to DNA.Molecular recognition of a carboxy pyridostatin toward G-quadruplex structures: Why does it prefer RNA?Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA.Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells A hitchhiker's guide to G-quadruplex ligands.Natural isoflavones regulate the quadruplex-duplex competition in human telomeric DNA G-quadruplex DNA bound by a synthetic ligand is highly dynamic.Human telomeric G-quadruplex: structures of DNA and RNA sequences.New Modalities for Challenging Targets in Drug Discovery.Affinity of the anthracycline antitumor drugs Doxorubicin and Sabarubicin for human telomeric G-quadruplex structures.The effects of molecular crowding on the structure and stability of g-quadruplexes with an abasic site.An overview of peptide and peptoid foldamers in medicinal chemistry.Computational Prediction and Rationalization, and Experimental Validation of Handedness Induction in Helical Aromatic Oligoamide Foldamers.Platinum(II) phenanthroimidazoles for targeting telomeric G-quadruplexes.Solution Observation of Dimerization and Helix Handedness Induction in a Human Carbonic Anhydrase-Helical Aromatic Amide Foldamer Complex.Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition.Controlled-folding of a small molecule modulates DNA G-quadruplex recognition G-quadruplex recognition by bis-indole carboxamides.Diarylethynyl amides that recognize the parallel conformation of genomic promoter DNA G-quadruplexes Shape-persistent H-bonded macrocyclic aromatic pentamers.Identifying G-quadruplex-binding ligands using DNA-functionalized gold nanoparticles.Size-dependent patterned recognition and extraction of metal ions by a macrocyclic aromatic pyridone pentamer.Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State.Asymmetric distyrylpyridinium dyes as red-emitting fluorescent probes for quadruplex DNA.Enantiomers of tetrahedral metal-organic cages: a new class of highly efficient G-quadruplex ligands with potential anticancer activities.Computation-guided improved one-pot synthesis of macrocyclic cation-binding aromatic pyridone pentamers.Methyl substitution regulates the enantioselectivity of supramolecular complex binding to human telomeric G-quadruplex DNA.Enantioselective sulfoxidation reaction catalyzed by a G-quadruplex DNA metalloenzyme.Chiral metallo-supramolecular complexes selectively induce human telomeric G-quadruplex formation under salt-deficient conditions.

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P2860

Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands

http://www.wikidata.org/entity/Q36376134

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands

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Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands

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type

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Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands

@ast

Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands

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prefLabel

Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands

@ast

Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands

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P1433

Journal of the American Chemical Society

P1476

Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands

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P2093

Elizabeth R Gillies

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Frédéric Godde

http://www.w3.org/2001/XMLSchema#string

Ivan Huc

http://www.w3.org/2001/XMLSchema#string

Kazuo Shin-Ya

http://www.w3.org/2001/XMLSchema#string

Pravin S Shirude

http://www.w3.org/2001/XMLSchema#string

Shankar Balasubramanian

http://www.w3.org/2001/XMLSchema#string

Sylvain Ladame

http://www.w3.org/2001/XMLSchema#string

P2860

Highly prevalent putative quadruplex sequence motifs in human DNA

Prevalence of quadruplexes in the human genome.

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo

Fluorescence resonance energy transfer as a probe for G-quartet formation by a telomeric repeat.

An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation.

Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus.

An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution

Four-stranded nucleic acid structures 25 years later: from guanosine gels to telomer DNA.

Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure.

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11890-11891

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scholarly article

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10.1021/JA073775H

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39

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129

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5995627

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17845042

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2195897

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