The conformational ensembles of α-synuclein and tau: combining single-molecule FRET and simulations.
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pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteinsA flash in the pan: dissecting dynamic amyloid intermediates using fluorescenceFunction and dysfunction of α-synuclein: probing conformational changes and aggregation by single molecule fluorescenceDirect force measurements reveal that protein Tau confers short-range attractions and isoform-dependent steric stabilization to microtubules.Multiply labeling proteins for studies of folding and stabilityConformations of a Metastable SH3 Domain Characterized by smFRET and an Excluded-Volume Polymer ModelComplex proteinopathy with accumulations of prion protein, hyperphosphorylated tau, α-synuclein and ubiquitin in experimental bovine spongiform encephalopathy of monkeys.The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation.Structural Insight into Tau Protein's Paradox of Intrinsically Disordered Behavior, Self-Acetylation Activity, and AggregationLabeling proteins with fluorophore/thioamide Förster resonant energy transfer pairs by combining unnatural amino acid mutagenesis and native chemical ligationHyperphosphorylation of intrinsically disordered tau protein induces an amyloidogenic shift in its conformational ensemble.Förster resonance energy transfer: Role of diffusion of fluorophore orientation and separation in observed shifts of FRET efficiency.Transient β-hairpin formation in α-synuclein monomer revealed by coarse-grained molecular dynamics simulation.Conformation and Dynamics of the Troponin I C-Terminal Domain: Combining Single-Molecule and Computational Approaches for a Disordered Protein Region.Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer.Comprehensive structural and dynamical view of an unfolded protein from the combination of single-molecule FRET, NMR, and SAXS.A functional role for intrinsic disorder in the tau-tubulin complex.Shedding light on protein folding landscapes by single-molecule fluorescence.Computational approaches to understanding protein aggregation in neurodegeneration.Cellular factors modulating the mechanism of tau protein aggregation.Comparison of force fields for Alzheimer's A β42: A case study for intrinsically disordered proteins.Understanding the dynamics of monomeric, dimeric, and tetrameric α-synuclein structures in water.Single-molecule FRET reveals hidden complexity in a protein energy landscape.Single-molecule assays for investigating protein misfolding and aggregation.Fluorescence spectroscopy reveals N-terminal order in fibrillar forms of α-synuclein.Using a FRET Library with Multiple Probe Pairs To Drive Monte Carlo Simulations of α-Synuclein.Insights into the Molecular Mechanisms of Alzheimer's and Parkinson's Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology.Characterizing highly dynamic conformational states: The transcription bubble in RNAP-promoter open complex as an example.CONAN: A Tool to Decode Dynamical Information from Molecular Interaction Maps.Contact between the β1 and β2 Segments of α-Synuclein that Inhibits Amyloid Formation.Intramolecular Diffusion in α-Synuclein: It Depends on How You Measure It
P2860
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P2860
The conformational ensembles of α-synuclein and tau: combining single-molecule FRET and simulations.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
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2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
@zh-hant
name
The conformational ensembles o ...... molecule FRET and simulations.
@ast
The conformational ensembles o ...... molecule FRET and simulations.
@en
type
label
The conformational ensembles o ...... molecule FRET and simulations.
@ast
The conformational ensembles o ...... molecule FRET and simulations.
@en
prefLabel
The conformational ensembles o ...... molecule FRET and simulations.
@ast
The conformational ensembles o ...... molecule FRET and simulations.
@en
P2093
P2860
P1433
P1476
The conformational ensembles o ...... molecule FRET and simulations.
@en
P2093
Adam J Trexler
Corey S O'Hern
David C DeWitt
Elizabeth Rhoades
Shana Elbaum-Garfinkle
P2860
P304
P356
10.1016/J.BPJ.2012.09.032
P407
P577
2012-11-01T00:00:00Z