Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor
about
Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticusRole of the first extracellular loop in the functional activation of CCR2. The first extracellular loop contains distinct domains necessary for both agonist binding and transmembrane signalingEvaluation of local MCP-1 and IL-12 nanocoatings for infection prevention in open fracturesPivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxisThe chemokine CCL18 causes maturation of cultured monocytes to macrophages in the M2 spectrumHIV-1 Tat protein mimicry of chemokinesAspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2Chemokine blockade: a new era in the treatment of rheumatoid arthritis?The monocyte-macrophage axis in the intestineDifferential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infectionsInfection-induced changes in hematopoiesisAAV-dominant negative tumor necrosis factor (DN-TNF) gene transfer to the striatum does not rescue medium spiny neurons in the YAC128 mouse model of Huntington's diseaseWound healing in MIP-1alpha(-/-) and MCP-1(-/-) miceCC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitisCC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cContrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virusCXCL17 is a major chemotactic factor for lung macrophagesMonocyte recruitment during infection and inflammationCCR2 modulates inflammatory and metabolic effects of high-fat feedingInnate and adaptive immunologic functions of complement in the host response to Listeria monocytogenes infection.Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects.Bone marrow-derived MCP1 required for experimental aortic aneurysm formation and smooth muscle phenotypic modulation.Natural killer cells regulate murine cytomegalovirus-induced sialadenitis and salivary gland disease.Bone marrow-derived cell-specific chemokine (C-C motif) receptor-2 expression is required for arteriolar remodeling.Capillary arterialization requires the bone-marrow-derived cell (BMC)-specific expression of chemokine (C-C motif) receptor-2, but BMCs do not transdifferentiate into microvascular smooth muscle.Loss of transforming growth factor-beta signaling in mammary fibroblasts enhances CCL2 secretion to promote mammary tumor progression through macrophage-dependent and -independent mechanismsMutant huntingtin impairs immune cell migration in Huntington disease.Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCR2 chemokine receptor deletion.The relative contributions of each subset of ocular infiltrated cells in experimental choroidal neovascularisation.Tunable chemokine production by antigen presenting dendritic cells in response to changes in regulatory T cell frequency in mouse reactive lymph nodes.CCR2-V64I polymorphism is associated with increased risk of cervical cancer but not with HPV infection or pre-cancerous lesions in African women.Induced Pluripotent Stem Cell-Derived Endothelial Cells Overexpressing Interleukin-8 Receptors A/B and/or C-C Chemokine Receptors 2/5 Inhibit Vascular Injury ResponseKey role of chemokines and chemokine receptors in inflammation, immunity, neoplasia, and infectious disease.Viral expression of CCL2 is sufficient to induce demyelination in RAG1-/- mice infected with a neurotropic coronavirus.Multiple roles of chemokine (C-C motif) ligand 2 in promoting prostate cancer growth.Truncation of the deubiquitinating domain of CYLD in myelomonocytic cells attenuates inflammatory responses.Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population.CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice.Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritisCNS leptin action modulates immune response and survival in sepsis.
P2860
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P2860
Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Defects in macrophage recruitm ...... ng the CCR2 chemokine receptor
@ast
Defects in macrophage recruitm ...... ng the CCR2 chemokine receptor
@en
type
label
Defects in macrophage recruitm ...... ng the CCR2 chemokine receptor
@ast
Defects in macrophage recruitm ...... ng the CCR2 chemokine receptor
@en
prefLabel
Defects in macrophage recruitm ...... ng the CCR2 chemokine receptor
@ast
Defects in macrophage recruitm ...... ng the CCR2 chemokine receptor
@en
P2093
P2860
P356
P1476
Defects in macrophage recruitm ...... ng the CCR2 chemokine receptor
@en
P2093
P2860
P304
P356
10.1084/JEM.186.10.1757
P407
P577
1997-11-01T00:00:00Z