Prothrombin activation by platelet-associated prothrombinase proceeds through the prethrombin-2 pathway via a concerted mechanism.
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Crystal Structure of Prothrombin Reveals Conformational Flexibility and Mechanism of ActivationThe linker connecting the two kringles plays a key role in prothrombin activationTACTIC: Trans-Agency Consortium for Trauma-Induced CoagulopathyNew insights into the spatiotemporal localization of prothrombinase in vivo.Prothrombin structure: unanticipated features and opportunities.MASP-1 Induced Clotting--The First Model of Prothrombin Activation by MASP-1.Kinetic dissection of the pre-existing conformational equilibrium in the trypsin fold.Prothrombin activation in blood coagulation: the erythrocyte contribution to thrombin generation.How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of ProthrombinThe transition of prothrombin to thrombin.Membrane binding by prothrombin mediates its constrained presentation to prothrombinase for cleavageHistone H4 promotes prothrombin autoactivation.The contribution of red blood cells to thrombin generation in sickle cell disease: meizothrombin generation on sickled red blood cells.Structural transitions during prothrombin activation: On the importance of fragment 2Spatiotemporal regulation of coagulation and platelet activation during the hemostatic response in vivo.Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant-anticoagulant equilibrium toward thrombosis.Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice.Impact of Non-Vitamin K Antagonist Oral Anticoagulants From a Basic Science Perspective.Probing the Dynamics of Clot-Bound Thrombin at Venous Shear Rates.Structure of prothrombin in the closed form reveals new details on the mechanism of activation.
P2860
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P2860
Prothrombin activation by platelet-associated prothrombinase proceeds through the prethrombin-2 pathway via a concerted mechanism.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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name
Prothrombin activation by plat ...... way via a concerted mechanism.
@ast
Prothrombin activation by plat ...... way via a concerted mechanism.
@en
type
label
Prothrombin activation by plat ...... way via a concerted mechanism.
@ast
Prothrombin activation by plat ...... way via a concerted mechanism.
@en
prefLabel
Prothrombin activation by plat ...... way via a concerted mechanism.
@ast
Prothrombin activation by plat ...... way via a concerted mechanism.
@en
P2093
P2860
P356
P1476
Prothrombin activation by plat ...... hway via a concerted mechanism
@en
P2093
Kenneth G Mann
Laura M Haynes
Paula B Tracy
P2860
P304
38647-38655
P356
10.1074/JBC.M112.407791
P407
P50
P577
2012-09-18T00:00:00Z