Neofunction of ACVR1 in fibrodysplasia ossificans progressiva. - Wikidata - awgldk - TriplyDB

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.

http://www.wikidata.org/entity/Q36394399

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Smad-dependent mechanisms of inflammatory bone destruction Urine-derived induced pluripotent stem cells as a modeling tool to study rare human diseases International physician survey on management of FOP: a modified Delphi study.Granting immunity to FOP and catching heterotopic ossification in the Act.High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva.Concurrent progress of reprogramming and gene correction to overcome therapeutic limitation of mutant ALK2-iPSC.The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.Structural Basis of Intracellular TGF-β Signaling: Receptors and Smads.TGF-β Family Signaling in Connective Tissue and Skeletal Diseases.Application of human induced pluripotent stem cells to model fibrodysplasia ossificans progressiva.Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification.Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling.Peripheral denervation participates in heterotopic ossification in a spinal cord injury model.Peripheral blood mononuclear cell immunophenotyping in fibrodysplasia ossificans progressiva patients: Evidence for monocyte DNAM1 up-regulation.New Models for Therapeutic Innovation from Japan.Towards a cure for Fibrodysplasia ossificans progressiva.A new form of IRIDA due to combined heterozygous mutations of TMPRSS6 and ACVR1A encoding the BMP receptor ALK2.Fibrodysplasia ossificans progressiva: Basic understanding and experimental models.Hard targets for a second skeleton: therapeutic horizons for fibrodysplasia ossificans progressiva (FOP).Variable signaling activity by FOP ACVR1 mutations.The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes.Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems.The Expansion of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva Is Activin A-Dependent.Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva.Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva.TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition.Animal models of fibrodysplasia ossificans progressiva.Variant BMP receptor mutations causing fibrodysplasia ossificans progressiva (FOP) in humans show BMP ligand-independent receptor activation in zebrafish.Stem cells and heterotopic ossification: Lessons from animal models.A Zebrafish Model of Human Fibrodysplasia Ossificans Progressiva.The Horizon of a Therapy for Rare Genetic Diseases: A "Druggable" Future for Fibrodysplasia Ossificans Progressiva.Current state of therapeutic development for rare cancers in Japan, and proposals for improvement.Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva Recent Topics in Fibrodysplasia Ossificans Progressiva Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity

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P2860

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.

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2015年学术文章

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2015年學術文章

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2015年學術文章

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2015年學術文章

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Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.

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Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.

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Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.

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Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.

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Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.

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Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.

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PNAS.1510540112

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Proceedings of the National Academy of Sciences of the United States of America

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Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.

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Hayao Ebise

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Junya Toguchida

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Kazuhiko Horigome

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Kazuya Sekiguchi

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Kyosuke Hino

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Megumi Nishio

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Mitsuaki Shibata

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Sanae Nagata

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Yoshihisa Matsumoto

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P2860

Novel regulators of bone formation: molecular clones and activities

The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities

A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva

Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva

TGFbeta signaling in growth control, cancer, and heritable disorders

Bone: formation by autoinduction

Bone morphogenetic protein receptors and signal transduction

ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation

The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo

Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis

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50

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112

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Shuichi Matsuda

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2015-11-30T00:00:00Z

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285386422

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26621707

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fibrodysplasia ossificans progressiva

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