Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7) [corrected]
about
Tetrodotoxin, an Extremely Potent Marine Neurotoxin: Distribution, Toxicity, Origin and Therapeutical UsesNa+ channel function, regulation, structure, trafficking and sequestrationBacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.Syntheses of Cyclic Guanidine-Containing Natural Products.Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison Frogs.Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNaV1.7.Shellfish toxins targeting voltage-gated sodium channels.Recent progress in neuroactive marine natural products.Saxitoxin.Emerging Targets in Photopharmacology.Heterologous expression of NaV1.9 chimeras in various cell systems.Synthesis of saxitoxin derivatives bearing guanidine and urea groups at C13 and evaluation of their inhibitory activity on voltage-gated sodium channels.A golden approach to ion channel inhibitionGuanidinium Toxins and Their Interactions with Voltage-Gated Sodium Ion Channels.Risks for public health related to the presence of tetrodotoxin (TTX) and TTX analogues in marine bivalves and gastropodsBiotechnological and Pharmacological Applications of Biotoxins and Other Bioactive Molecules from Dinoflagellates.Differential binding of tetrodotoxin and its derivatives to voltage-sensitive sodium channel subtypes (Nav 1.1 to Nav 1.7).Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin StudiesMutations in Sodium Channel Gene SCN9A and the Pain Perception DisordersEvaluation of toxicity equivalent factors of paralytic shellfish poisoning toxins in seven human sodium channels types by an automated high throughput electrophysiology system
P2860
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P2860
Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7) [corrected]
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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name
Marked difference in saxitoxin ...... m channel (Nav1.7) [corrected]
@ast
Marked difference in saxitoxin ...... m channel (Nav1.7) [corrected]
@en
type
label
Marked difference in saxitoxin ...... m channel (Nav1.7) [corrected]
@ast
Marked difference in saxitoxin ...... m channel (Nav1.7) [corrected]
@en
prefLabel
Marked difference in saxitoxin ...... m channel (Nav1.7) [corrected]
@ast
Marked difference in saxitoxin ...... m channel (Nav1.7) [corrected]
@en
P2093
P2860
P356
P1476
Marked difference in saxitoxin ...... m channel (Nav1.7) [corrected]
@en
P2093
James R Walker
Jeff Zablocki
Malcolm McGregor
Paul A Novick
Vijay S Pande
P2860
P304
18102-18107
P356
10.1073/PNAS.1206952109
P407
P577
2012-10-17T00:00:00Z