about
Structural conservation of druggable hot spots in protein-protein interfacesFrom modules to medicine: How modular domains and their associated networks can enable personalized medicineStructural Insight into the Kinetics and Cp of Interactions between TEM-1 -Lactamase and -Lactamase Inhibitory Protein (BLIP)Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture MechanismFrom Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.Exploring the Binding Nature of Pyrrolidine Pocket-Dependent Interactions in the Polo-Box Domain of Polo-Like Kinase 1Oxime side-chain cross-links in an α-helical coiled-coil protein: structure, thermodynamics, and folding-templated synthesis of bicyclic speciesDesigning focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methodsInterrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinityInterface-resolved network of protein-protein interactionsEvidence of conformational selection driving the formation of ligand binding sites in protein-protein interfacesModulating protein-protein interactions with small molecules: the importance of binding hotspots.Non-peptidic thrombospondin-1 mimics as fibroblast growth factor-2 inhibitors: an integrated strategy for the development of new antiangiogenic compounds.Novel peptide ligands of RGS4 from a focused one-bead, one-compound library.Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective.High-throughput screening for modulators of protein-protein interactions: use of photonic crystal biosensors and complementary technologies.β-Turn mimetic-based stabilizers of protein-protein interactions for the study of the non-canonical roles of leucyl-tRNA synthetase.Structural basis for the modulation of CDK-dependent/independent activity of cyclin D1.Targeting protein-protein interactions for therapeutic intervention: a challenge for the future.Role of natural product diversity in chemical biology.Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in miceProtein engineering of the N-terminus of NEMO: structure stabilization and rescue of IKKβ binding.Small-molecule modulators of the OX40-OX40 ligand co-stimulatory protein-protein interactionStructure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid.Identification of Small-Molecule Frequent Hitters from AlphaScreen High-Throughput Screens.Direct comparison of linear and macrocyclic compound libraries as a source of protein ligandsHow proteins bind macrocycles.The discovery of LOX-1, its ligands and clinical significance.TNF superfamily protein-protein interactions: feasibility of small- molecule modulationMedicinal chemistry for 2020Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?New Frontiers in DruggabilityState-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.Design of protein membrane interaction inhibitors by virtual ligand screening, proof of concept with the C2 domain of factor VAlphaSpace: Fragment-Centric Topographical Mapping To Target Protein-Protein Interaction Interfaces.PocketQuery: protein-protein interaction inhibitor starting points from protein-protein interaction structure.Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A.DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites.Relationship between hot spot residues and ligand binding hot spots in protein-protein interfaces.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Between a rock and a hard place?
@ast
Between a rock and a hard place?
@en
type
label
Between a rock and a hard place?
@ast
Between a rock and a hard place?
@en
prefLabel
Between a rock and a hard place?
@ast
Between a rock and a hard place?
@en
P356
P1476
Between a rock and a hard place?
@en
P2093
Adrian Whitty
Gnanasambandam Kumaravel
P2888
P304
P356
10.1038/NCHEMBIO0306-112
P577
2006-03-01T00:00:00Z
P6179
1015718784