Site-specific chemical protein conjugation using genetically encoded aldehyde tags
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Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs)Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer TherapeuticsSite-specific functionalization of proteins and their applications to therapeutic antibodiesThe Structure of Human GALNS Reveals the Molecular Basis for Mucopolysaccharidosis IV AX-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modificationSubstrate selectivity analyses of factor inhibiting hypoxia-inducible factorGenetically Directed Production of Recombinant, Isosteric and Nonhydrolysable Ubiquitin ConjugatesDevelopment and Evaluation of a Fluorescent Antibody-Drug Conjugate for Molecular Imaging and Targeted Therapy of Pancreatic CancerAdapter reagents for protein site specific dye labelingEnzymatic labeling of proteins: techniques and approachesWorld Antibody-Drug Conjugate Summit, October 15-16, 2013, San Francisco, CA.Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineeringIn vitro and in vivo application of anti-cotinine antibody and cotinine-conjugated compounds.Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomesSortase-mediated modification of αDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes.Computational Construction of Antibody-Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable LinkerMethods to Make Homogenous Antibody Drug Conjugates.Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion.Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper(II).PRINT: A Protein Bioconjugation Method with Exquisite N-terminal Specificity.Bringing single-molecule spectroscopy to macromolecular protein complexes.Glycoprotein disease markers and single protein-omicsField Guide to Challenges and Opportunities in Antibody-Drug Conjugates for Chemists.A general method for fluorescent labeling of the N-termini of lanthipeptides and its application to visualize their cellular localization.Precision glycocalyx editing as a strategy for cancer immunotherapy.Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes.Site-specific antibody drug conjugates for cancer therapyExterior design: strategies for redecorating the bacterial surface with small molecules.Therapeutic applications of an expanded genetic code.Formylglycine, a post-translationally generated residue with unique catalytic capabilities and biotechnology applications.Single-molecule sorting of DNA helicases.A modular approach for assembling aldehyde-tagged proteins on DNA scaffolds.Stable and Potent Selenomab-Drug Conjugates.Antibody-Drug Conjugates: Design, Formulation and Physicochemical Stability.Emerging site-specific bioconjugation strategies for radioimmunotracer development.Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates.Microbial transglutaminase and c-myc-tag: a strong couple for the functionalization of antibody-like protein scaffolds from discovery platforms.Quantifying the Assembly of Multicomponent Molecular Machines by Single-Molecule Total Internal Reflection Fluorescence MicroscopyChemoenzymatic Fc glycosylation via engineered aldehyde tags.Site-Specific Tandem Knoevenagel Condensation-Michael Addition To Generate Antibody-Drug Conjugates.
P2860
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P2860
Site-specific chemical protein conjugation using genetically encoded aldehyde tags
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
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name
Site-specific chemical protein conjugation using genetically encoded aldehyde tags
@ast
Site-specific chemical protein conjugation using genetically encoded aldehyde tags
@en
type
label
Site-specific chemical protein conjugation using genetically encoded aldehyde tags
@ast
Site-specific chemical protein conjugation using genetically encoded aldehyde tags
@en
prefLabel
Site-specific chemical protein conjugation using genetically encoded aldehyde tags
@ast
Site-specific chemical protein conjugation using genetically encoded aldehyde tags
@en
P2093
P2860
P356
P1433
P1476
Site-specific chemical protein conjugation using genetically encoded aldehyde tags
@en
P2093
Gregory W deHart
Jason S Rush
P2860
P2888
P304
P356
10.1038/NPROT.2012.045
P577
2012-05-10T00:00:00Z