Endogenous myelin basic protein inactivates the high avidity T cell repertoire
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An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanismsUse of recombinant lentivirus pseudotyped with vesicular stomatitis virus glycoprotein G for efficient generation of human anti-cancer chimeric T cells by transduction of human peripheral blood lymphocytes in vitro.How frequently are predicted peptides actually recognized by CD8 cells?Role of T cell-glial cell interactions in creating and amplifying central nervous system inflammation and multiple sclerosis disease symptomsRelapsing-remitting central nervous system autoimmunity mediated by GFAP-specific CD8 T cells.ELISPOT Assays in 384-Well Format: Up to 30 Data Points with One Million Cells.On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease.Theiler's virus infection induces a predominant pathogenic CD4+ T cell response to RNA polymerase in susceptible SJL/J miceMolecular mimicry and multiple sclerosis: degenerate T-cell recognition and the induction of autoimmunity.Mechanisms of central and peripheral T-cell tolerance: lessons from experimental models of multiple sclerosis.Tolerance and autoimmunity in TCR transgenic mice specific for myelin basic protein.An affinity/avidity model of peripheral T cell regulationThe function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease.Manipulating antigenic ligand strength to selectively target myelin-reactive CD4+ T cells in EAE.TCR affinity for self-ligands influences the development and function of encephalitogenic T cells.The myelin basic protein gene is expressed in differentiated blood cell lineages and in hemopoietic progenitors.Capsid-specific cytotoxic T lymphocytes recognize three distinct H-2D(b)-restricted regions of the BeAn strain of Theiler's virus and exhibit different cytokine profilesThe majority of infiltrating CD8+ T cells in the central nervous system of susceptible SJL/J mice infected with Theiler's virus are virus specific and fully functional.Differences in avidity and epitope recognition of CD8(+) T cells infiltrating the central nervous systems of SJL/J mice infected with BeAn and DA strains of Theiler's murine encephalomyelitis virusImmune tolerance in multiple sclerosis.Peripheral expression of ocular antigens in regulation and therapy of ocular autoimmunity.Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor.Preclinical development and first-in-human study of ATX-MS-1467 for immunotherapy of MSMyelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice.Neonatal induction of myelin-specific Th1/Th17 immunity does not result in experimental autoimmune encephalomyelitis and can protect against the disease in adulthood.Depletion of CD4(+)CD25(+) T cells exacerbates experimental autoimmune encephalomyelitis induced by mouse, but not rat, antigensAutoantibodies to vimentin cause accelerated rejection of cardiac allografts.Oral administration of live virus protects susceptible mice from developing Theiler's virus-induced demyelinating disease.Characterization of the HCMV-Specific CD4 T Cell Responses that Are Associated with Protective ImmunityThe relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes.Cytotoxic T lymphocytes to an unmutated tumor rejection antigen P1A: normal development but restrained effector function in vivo.Regulation of interleukin (IL)-12 receptor beta2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells.Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes.The stimulation of low-affinity, nontolerized clones by heteroclitic antigen analogues causes the breaking of tolerance established to an immunodominant T cell epitope.Tolerating the nervous system: a delicate balanceHigh frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire.Negative selection during the peripheral immune response to antigen.A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis.How much of virus-specific CD8 T cell reactivity is detected with a peptide pool when compared to individual peptides?In vivo expansion of the residual tumor antigen-specific CD8+ T lymphocytes that survive negative selection in simian virus 40 T-antigen-transgenic mice.
P2860
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P2860
Endogenous myelin basic protein inactivates the high avidity T cell repertoire
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Endogenous myelin basic protein inactivates the high avidity T cell repertoire
@ast
Endogenous myelin basic protein inactivates the high avidity T cell repertoire
@en
type
label
Endogenous myelin basic protein inactivates the high avidity T cell repertoire
@ast
Endogenous myelin basic protein inactivates the high avidity T cell repertoire
@en
prefLabel
Endogenous myelin basic protein inactivates the high avidity T cell repertoire
@ast
Endogenous myelin basic protein inactivates the high avidity T cell repertoire
@en
P2860
P356
P1476
Endogenous myelin basic protein inactivates the high avidity T cell repertoire
@en
P2093
O S Targoni
P V Lehmann
P2860
P304
P356
10.1084/JEM.187.12.2055
P407
P577
1998-06-01T00:00:00Z