Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis
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Regulating the immune system via IL-15 transpresentationInterleukin-7 and interleukin-15 for cancerMolecular mechanism and cellular function of MHCII ubiquitinationCrystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in transCrystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentationNK cells in the tumor microenvironment.STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cellsMature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activityIntramuscular delivery of heterodimeric IL-15 DNA in macaques produces systemic levels of bioactive cytokine inducing proliferation of NK and T cellsA LysM and SH3-domain containing region of the Listeria monocytogenes p60 protein stimulates accessory cells to promote activation of host NK cells.Generation of a novel regulatory NK cell subset from peripheral blood CD34+ progenitors promoted by membrane-bound IL-15Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer.Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15Ralpha.Interleukin-15 and its receptor augment dendritic cell vaccination against the neu oncogene through the induction of antibodies partially independent of CD4 help.Plasmid-encoded interleukin-15 receptor alpha enhances specific immune responses induced by a DNA vaccine in vivo.IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection.Rapid release of cytoplasmic IL-15 from tumor-associated macrophages is an initial and critical event in IL-12-initiated tumor regression.Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo.IL-15.IL-15Rα complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cellsA Poly(Lactic-co-Glycolic) Acid Nanovaccine Based on Chimeric Peptides from Different Leishmania infantum Proteins Induces Dendritic Cells Maturation and Promotes Peptide-Specific IFNγ-Producing CD8+ T Cells Essential for the Protection against ExpeDeciphering the role of DC subsets in MCMV infection to better understand immune protection against viral infectionsIL-18, but not IL-15, contributes to the IL-12-dependent induction of NK-cell effector functions by Leishmania infantum in vivo.In vivo role of Flt3 ligand and dendritic cells in NK cell homeostasisThymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation.Highly potent anti-CD20-RLI immunocytokine targeting established human B lymphoma in SCID mouse.Expression of IL-15RA or an IL-15/IL-15RA fusion on CD8+ T cells modifies adoptively transferred T-cell function in cisAltered IL-7Ralpha expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses.Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection.A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza infection.Molecular mechanisms influencing NK cell development: implications for NK cell malignancies.Primary human T lymphocytes engineered with a codon-optimized IL-15 gene resist cytokine withdrawal-induced apoptosis and persist long-term in the absence of exogenous cytokine.Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}Characterization and favorable in vivo properties of heterodimeric soluble IL-15·IL-15Rα cytokine compared to IL-15 monomer.Inhibition of tumor growth by NK1.1+ cells and CD8+ T cells activated by IL-15 through receptor beta/common gamma signaling in trans.Hyper-IL-15 suppresses metastatic and autochthonous liver cancer by promoting tumour-specific CD8+ T cell responses.Acupuncture May Stimulate Anticancer Immunity via Activation of Natural Killer Cells.MHC class I and TCR avidity control the CD8 T cell response to IL-15/IL-15Rα complex.Homeostatic control of memory cell progenitors in the natural killer cell lineageThe IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cellsSelective reduction of post-selection CD8 thymocyte proliferation in IL-15Rα deficient mice.
P2860
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P2860
Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Coordinate expression and tran ...... memory CD8+ T cell homeostasis
@ast
Coordinate expression and tran ...... memory CD8+ T cell homeostasis
@en
type
label
Coordinate expression and tran ...... memory CD8+ T cell homeostasis
@ast
Coordinate expression and tran ...... memory CD8+ T cell homeostasis
@en
prefLabel
Coordinate expression and tran ...... memory CD8+ T cell homeostasis
@ast
Coordinate expression and tran ...... memory CD8+ T cell homeostasis
@en
P2093
P2860
P356
P1476
Coordinate expression and tran ...... memory CD8+ T cell homeostasis
@en
P2093
David L Boone
Marcia Chien
Patrick R Burkett
Sophia Chai
P2860
P304
P356
10.1084/JEM.20041389
P407
P50
P577
2004-09-27T00:00:00Z