Basophils initiate IL-4 production during a memory T-dependent response.
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Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsionStructural similarities of human and mammalian lipocalins, and their function in innate immunity and allergyCationic amino acid transporter 2 regulates inflammatory homeostasis in the lungA two-step process for cytokine production revealed by IL-4 dual-reporter mice.New paradigms in type 2 immunity.A mechanism for the initiation of allergen-induced T helper type 2 responsesIgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking.Human cord blood derived immature basophils show dual characteristics, expressing both basophil and eosinophil associated proteins.Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion.Rapid polyclonal desensitization with antibodies to IgE and FcεRIαThe T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation.Identification of markers that distinguish IgE- from IgG-mediated anaphylaxis.Systemic impact of intestinal helminth infections.Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system.Basophils are the major producers of IL-4 during primary helminth infection.IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms.Neutrophils clear bacteria associated with parasitic nematodes augmenting the development of an effective Th2-type response.Pathways of murine mast cell development and trafficking: tracking the roots and routes of the mast cell.Cytokine concentrations in bronchoalveolar lavage fluid from horses with neutrophilic inflammatory airway disease.NOD2 and TLR2 ligands trigger the activation of basophils and eosinophils by interacting with dermal fibroblasts in atopic dermatitis-like skin inflammationSTAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infectionBasophils: what they 'can do' versus what they 'actually do'.IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleenIL-3 is required for increases in blood basophils in nematode infection in mice and can enhance IgE-dependent IL-4 production by basophils in vitroEmerging role of human basophil biology in health and disease.New paradigms in basophil development, regulation and function.Newly appreciated roles for basophils in allergy and protective immunity.Basophil-derived IL-4 plays versatile roles in immunity.Basophils inhibit proliferation of CD4⁺ T cells in autologous and allogeneic mixed lymphocyte reactions and limit disease activity in a murine model of graft versus host disease.The skin is an important bulwark of acquired immunity against intestinal helminths.Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy.Regulation of the Il4 gene is independently controlled by proximal and distal 3' enhancers in mast cells and basophils.Peanuts can contribute to anaphylactic shock by activating complement.The vascular endothelial specific IL-4 receptor alpha-ABL1 kinase signaling axis regulates the severity of IgE-mediated anaphylactic reactions.The spleen is the site where mast cells are induced in the development of food allergy.Bronchoalveolar lavage fluid cytology and cytokine messenger ribonucleic Acid expression of racehorses with exercise intolerance and lower airway inflammation.Fundamental role of dendritic cells in inducing Th2 responses.
P2860
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P2860
Basophils initiate IL-4 production during a memory T-dependent response.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
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2004年學術文章
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name
Basophils initiate IL-4 production during a memory T-dependent response.
@ast
Basophils initiate IL-4 production during a memory T-dependent response.
@en
type
label
Basophils initiate IL-4 production during a memory T-dependent response.
@ast
Basophils initiate IL-4 production during a memory T-dependent response.
@en
prefLabel
Basophils initiate IL-4 production during a memory T-dependent response.
@ast
Basophils initiate IL-4 production during a memory T-dependent response.
@en
P2093
P2860
P356
P1476
Basophils initiate IL-4 production during a memory T-dependent response.
@en
P2093
Crystal Potter
Fred D Finkelman
Marat V Khodoun
Suzanne Morris
Tatyana Orekhova
P2860
P304
P356
10.1084/JEM.20040598
P407
P577
2004-10-01T00:00:00Z