Direct oxidation and covalent binding of isoniazid to rodent liver and human hepatic microsomes: humans are more like mice than rats.
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Evaluation of database-derived pathway development for enabling biomarker discovery for hepatotoxicityIsoniazid metabolism and hepatotoxicityMechanism of isoniazid‐induced hepatotoxicity: then and nowReal-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing.A systems biology approach utilizing a mouse diversity panel identifies genetic differences influencing isoniazid-induced microvesicular steatosis.Protective effects of metallothionein on isoniazid and rifampicin-induced hepatotoxicity in mice.Population pharmacokinetic analysis of isoniazid, acetylisoniazid, and isonicotinic acid in healthy volunteersHuman PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy.Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failureRole of Inflammatory and Oxidative Stress, Cytochrome P450 2E1, and Bile Acid Disturbance in Rat Liver Injury Induced by Isoniazid and Lipopolysaccharide Cotreatment.Dexamethasone Pretreatment Alleviates Isoniazid/Lipopolysaccharide Hepatotoxicity: Inhibition of Inflammatory and Oxidative Stress.Role of CYP3A in isoniazid metabolism in vivoMechanisms of isoniazid-induced idiosyncratic liver injury: emerging role of mitochondrial stress.Biotransformation and bioactivation reactions of alicyclic amines in drug molecules.Hepatotoxicity mechanisms of isoniazid: A mini-review.Non-cytochrome P450-mediated bioactivation and its toxicological relevance.A High Dose of Isoniazid Disturbs Endobiotic Homeostasis in Mouse LiverIsoniazid hepatotoxicity: progress in understanding the immunologic component.Lack of liver injury in Wistar rats treated with the combination of isoniazid and rifampicin.Kinetics and mechanism of oxidation of the anti-tubercular prodrug isoniazid and its analog by iridium(iv) as models for biological redox systems.Isoniazid-induced liver injury and immune response in mice.Deficiency of N-acetyltransferase increases the interactions of isoniazid with endobiotics in mouse liver.Treatment of PD-1(-/-) mice with amodiaquine and anti-CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients.Development of a novel mouse model of amodiaquine-induced liver injury with a delayed onset.From the Cover: Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury.Investigating the CYP2E1 Potential Role in the Mechanisms Behind INH/LPS-Induced Hepatotoxicity.Hepatic effects of aminoglutethimide: a model aromatic amine.The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats.Disseminated Granulomatous Disease from Intravesical Instillation of Bacillus Calmette-Guerin
P2860
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P2860
Direct oxidation and covalent binding of isoniazid to rodent liver and human hepatic microsomes: humans are more like mice than rats.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Direct oxidation and covalent ...... are more like mice than rats.
@ast
Direct oxidation and covalent ...... are more like mice than rats.
@en
type
label
Direct oxidation and covalent ...... are more like mice than rats.
@ast
Direct oxidation and covalent ...... are more like mice than rats.
@en
prefLabel
Direct oxidation and covalent ...... are more like mice than rats.
@ast
Direct oxidation and covalent ...... are more like mice than rats.
@en
P2093
P2860
P356
P1476
Direct oxidation and covalent ...... are more like mice than rats.
@en
P2093
Imir G Metushi
Jack Uetrecht
Tetsuya Nakagawa
P2860
P304
P356
10.1021/TX300341R
P577
2012-10-16T00:00:00Z