Cell of origin determines clinically relevant subtypes of MLL-rearranged AML - Wikidata - awgldk - TriplyDB

Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

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Recent progress toward epigenetic therapies: the example of mixed lineage leukemia Current concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia Epigenetic regulation of hematopoietic stem cell aging Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update Tumour heterogeneity and cancer cell plasticity Frequency of acute myeloid leukaemia-associated mouse chromosome 2 deletions in X-ray exposed immature haematopoietic progenitors and stem cells.Arsenic trioxide induces apoptosis in the THP1 cell line by downregulating EVI-1 Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4.Heterogeneity of clonal expansion and maturation-linked mutation acquisition in hematopoietic progenitors in human acute myeloid leukemia.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.KRas(G12D)-evoked leukemogenesis does not require β-catenin.DNA damage: a sensible mediator of the differentiation decision in hematopoietic stem cells and in leukemia.Dissecting the role of aberrant DNA methylation in human leukaemia.Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing An LSC epigenetic signature is largely mutation independent and implicates the HOXA cluster in AML pathogenesis.Systematic analysis of hematopoietic gene expression profiles for prognostic prediction in acute myeloid leukemia.Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia Delineating the mixed lineage leukemia gene expression network in hematopoietic stem cells.Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells.CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity.Prognostic Significance of Mixed-Lineage Leukemia (MLL) Gene Detected by Real-Time Fluorescence Quantitative PCR Assay in Acute Myeloid Leukemia.Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia.EVI1 expression in childhood acute lymphoblastic leukaemia is not restricted to MLL and BCR/ABL rearrangements and is influenced by age.MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.Bisulfighter: accurate detection of methylated cytosines and differentially methylated regions.Origins of aberrant DNA methylation in acute myeloid leukemia.Molecular pathogenesis of AML: translating insights to the clinic.Targeting novel signaling pathways for resistant acute myeloid leukemia.Review: Aberrant EVI1 expression in acute myeloid leukaemia.Genome Organization Drives Chromosome Fragility.Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease.Biology and relevance of human acute myeloid leukemia stem cells.Roles of IDH1/2 and TET2 mutations in myeloid disorders.BET inhibitor resistance emerges from leukaemia stem cells.MLL-ENL-mediated leukemia initiation at the interface of lymphoid commitment.Mouse models of MLL leukemia: recapitulating the human disease Dysregulation of haematopoietic stem cell regulatory programs in acute myeloid leukaemia.

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P2860

Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

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Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

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Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

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Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

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Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

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Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

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Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

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Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

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A M Melnick

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A U Sinha

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A V Krivtsov

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L Bullinger

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S A Armstrong

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Z Feng

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P2860

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B.

Expression and prognostic significance of different mRNA 5'-end variants of the oncogene EVI1 in 266 patients with de novo AML: EVI1 and MDS1/EVI1 overexpression both predict short remission duration

The epigenomics of cancer

Epigenetic memory in induced pluripotent stem cells

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

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4

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27

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Maria E Figueroa

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2012-12-13T00:00:00Z

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