Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice.
about
Interplay between cytosolic disulfide reductase systems and the Nrf2/Keap1 pathwayThe role of Nrf2: adipocyte differentiation, obesity, and insulin resistancePFOS induces adipogenesis and glucose uptake in association with activation of Nrf2 signaling pathwayEffects of developmental deltamethrin exposure on white adipose tissue gene expressionHepatic oxidative stress, genotoxicity and vascular dysfunction in lean or obese Zucker ratsIncreased Energy Expenditure, Ucp1 Expression, and Resistance to Diet-induced Obesity in Mice Lacking Nuclear Factor-Erythroid-2-related Transcription Factor-2 (Nrf2)Sulforaphane Protects against Cardiovascular Disease via Nrf2 ActivationMechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative diseaseChronic Activation of Hepatic Nrf2 Has No Major Effect on Fatty Acid and Glucose Metabolism in Adult MiceThe paradox of bardoxolone methyl: a call for every witness on the stand?Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy.Caenorhabditis elegans: A useful model for studying metabolic disorders in which oxidative stress is a contributing factor.Activation of the Nrf2-ARE pathway in hepatocytes protects against steatosis in nutritionally induced non-alcoholic steatohepatitis in miceDimethylfumarate suppresses adipogenic differentiation in 3T3-L1 preadipocytes through inhibition of STAT3 activityDeficiency in Nrf2 transcription factor decreases adipose tissue mass and hepatic lipid accumulation in leptin-deficient miceKeap1-knockdown decreases fasting-induced fatty liver via altered lipid metabolism and decreased fatty acid mobilization from adipose tissueBerberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and lncRNA expression profilesTargeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stressEstrogen Sulfotransferase Is an Oxidative Stress-responsive Gene That Gender-specifically Affects Liver Ischemia/Reperfusion InjuryRestoration of Nrf2 Signaling Normalizes the Regenerative Niche.Female spontaneously diabetic Torii fatty rats develop nonalcoholic steatohepatitis-like hepatic lesionsMulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed miceNew player on an old field; the keap1/Nrf2 pathway as a target for treatment of type 2 diabetes and metabolic syndrome.Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy.Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feedingMagnolia extract (BL153) ameliorates kidney damage in a high fat diet-induced obesity mouse modelAutophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cell.Nuclear factor (erythroid-derived 2)-like 2 activation-induced hepatic very-low-density lipoprotein receptor overexpression in response to oxidative stress contributes to alcoholic liver disease in mice.Combating oxidative stress in diabetic complications with Nrf2 activators: how much is too much?Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPAR γ Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease.Diabetic cardiomyopathy and its prevention by nrf2: current status.The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome.Altered hepatic lipid metabolism contributes to nonalcoholic fatty liver disease in leptin-deficient Ob/Ob mice.Protective role of sulphoraphane against vascular complications in diabetes.The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update.Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosisCaloric restriction-mediated induction of lipid metabolism gene expression in liver is enhanced by Keap1-knockdownFrom the Cover: Zinc Deficiency Worsens and Supplementation Prevents High-Fat Diet Induced Vascular Inflammation, Oxidative Stress, and Pathological Remodeling.Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity.Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways.
P2860
Q26778366-E5144BF5-376C-42BD-8C77-7BF44A52359EQ26825024-364359A0-36E5-42E6-877C-B89CB258C09DQ28385987-B78D9489-97A4-4027-A450-C9192534C7DEQ28386680-B1750886-400F-4C94-8526-16F10A96690BQ28389287-1EE4DB63-A39C-40F4-A084-C2EF3C3DCF3FQ28391076-B47F44CC-A3FA-4E9A-8324-531D3AE6EBFFQ28393421-C1099106-73EE-4FB0-A3F4-9734FFDEB5DBQ28394732-5BF1FF55-2CF7-46B5-9BBE-EE0D0F8B2222Q32186681-5B4F17C1-919C-4D84-8C3B-4A536A71EA1BQ33358784-AAD29156-33C0-4BD7-87F8-C056AF72B9ECQ33645497-C1FF9B65-FCA9-4CD3-974A-16CAA94F6287Q33736292-01F05212-BB2E-4A5A-8E96-9E0652C14B58Q34605967-424B6EE2-A115-4174-916C-3D6A8211E4D6Q34700280-24BF6E3E-2EA6-4C9F-B552-437BBADFD1B6Q35027768-2CC3DA3F-92C3-4E97-A3B2-3362CBAD68C0Q35041508-539BEAD5-07D0-4D07-A088-1E09EE1A4738Q35047942-E5D8E6A3-A3B2-4A5D-80E2-E2E9B6095EF4Q35801045-6559F7F1-4952-4244-961B-6F96293DF84AQ35860863-8FFD6338-4038-4933-8EED-CB2195F8BF10Q35863707-10ACECD4-9510-4B8F-8030-2ACDA1CF0B21Q35942391-0CC63188-CD3A-467C-96F4-55D822286554Q36157579-F7C1B552-D2D9-4450-AF75-FA65620EF8C6Q36695768-223103D3-1F95-4261-9E4B-5579B00E7DD7Q36736742-762E3ADD-1EDD-4E4B-B795-60FC0D1A3CF3Q37231144-54D7828A-C656-45C2-A5FB-172308E68A26Q37393066-A740672F-1E5B-4D3C-BFB7-6A10ACA0A887Q37544826-E7C761BA-DBFD-4C56-92D6-6902809C5BB4Q37666136-E175C97F-333C-41A4-A2EA-BA0042E192A8Q38190096-C314BCB6-0549-4F93-AD1A-8EE1EDD82E25Q38207591-69C5B32E-4CC2-4A04-83B8-209D4B8129E6Q38263221-39E9D834-5980-465E-A6B6-997CF06DFAAFQ38300447-FBE446F8-3E07-410D-A631-B15DC15E5E8FQ38317751-41063AD0-3F92-4B72-86C4-980205D33031Q38721709-65987E14-621F-4537-A3D2-35AB753DD5FEQ38837451-79E1FAE9-BBA8-4C4A-927C-B6413EB3C8DBQ39000961-4F0ACB55-ADFB-49BF-8765-E15938703A3BQ42108839-289CEF0C-0064-492F-A83E-A8D74C375395Q42695381-5B910BB7-49D3-4F45-A4FC-559C2F58A81FQ45926436-DC2B1F54-D76C-4B4C-9C16-7866E55445BCQ46241203-A34F715D-3EF5-4373-AE38-EE34BE9A01BD
P2860
Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Enhanced Nrf2 activity worsens ...... osis in leptin-deficient mice.
@ast
Enhanced Nrf2 activity worsens ...... osis in leptin-deficient mice.
@en
type
label
Enhanced Nrf2 activity worsens ...... osis in leptin-deficient mice.
@ast
Enhanced Nrf2 activity worsens ...... osis in leptin-deficient mice.
@en
prefLabel
Enhanced Nrf2 activity worsens ...... osis in leptin-deficient mice.
@ast
Enhanced Nrf2 activity worsens ...... osis in leptin-deficient mice.
@en
P2093
P2860
P356
P1433
P1476
Enhanced Nrf2 activity worsens ...... tosis in leptin-deficient mice
@en
P2093
Ajay C Donepudi
Angela L Slitt
Vijay R More
P2860
P304
P356
10.2337/DB11-1716
P407
P577
2012-08-30T00:00:00Z