Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice. - Wikidata - awgldk - TriplyDB

Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice.

Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice.

http://www.wikidata.org/entity/Q36410781

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Interplay between cytosolic disulfide reductase systems and the Nrf2/Keap1 pathway The role of Nrf2: adipocyte differentiation, obesity, and insulin resistance PFOS induces adipogenesis and glucose uptake in association with activation of Nrf2 signaling pathway Effects of developmental deltamethrin exposure on white adipose tissue gene expression Hepatic oxidative stress, genotoxicity and vascular dysfunction in lean or obese Zucker rats Increased Energy Expenditure, Ucp1 Expression, and Resistance to Diet-induced Obesity in Mice Lacking Nuclear Factor-Erythroid-2-related Transcription Factor-2 (Nrf2)Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease Chronic Activation of Hepatic Nrf2 Has No Major Effect on Fatty Acid and Glucose Metabolism in Adult Mice The paradox of bardoxolone methyl: a call for every witness on the stand?Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy.Caenorhabditis elegans: A useful model for studying metabolic disorders in which oxidative stress is a contributing factor.Activation of the Nrf2-ARE pathway in hepatocytes protects against steatosis in nutritionally induced non-alcoholic steatohepatitis in mice Dimethylfumarate suppresses adipogenic differentiation in 3T3-L1 preadipocytes through inhibition of STAT3 activity Deficiency in Nrf2 transcription factor decreases adipose tissue mass and hepatic lipid accumulation in leptin-deficient mice Keap1-knockdown decreases fasting-induced fatty liver via altered lipid metabolism and decreased fatty acid mobilization from adipose tissue Berberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and lncRNA expression profiles Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stress Estrogen Sulfotransferase Is an Oxidative Stress-responsive Gene That Gender-specifically Affects Liver Ischemia/Reperfusion Injury Restoration of Nrf2 Signaling Normalizes the Regenerative Niche.Female spontaneously diabetic Torii fatty rats develop nonalcoholic steatohepatitis-like hepatic lesions Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice New player on an old field; the keap1/Nrf2 pathway as a target for treatment of type 2 diabetes and metabolic syndrome.Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy.Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding Magnolia extract (BL153) ameliorates kidney damage in a high fat diet-induced obesity mouse model Autophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cell.Nuclear factor (erythroid-derived 2)-like 2 activation-induced hepatic very-low-density lipoprotein receptor overexpression in response to oxidative stress contributes to alcoholic liver disease in mice.Combating oxidative stress in diabetic complications with Nrf2 activators: how much is too much?Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPAR γ Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease.Diabetic cardiomyopathy and its prevention by nrf2: current status.The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome.Altered hepatic lipid metabolism contributes to nonalcoholic fatty liver disease in leptin-deficient Ob/Ob mice.Protective role of sulphoraphane against vascular complications in diabetes.The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update.Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis Caloric restriction-mediated induction of lipid metabolism gene expression in liver is enhanced by Keap1-knockdown From the Cover: Zinc Deficiency Worsens and Supplementation Prevents High-Fat Diet Induced Vascular Inflammation, Oxidative Stress, and Pathological Remodeling.Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity.Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways.

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P2860

Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice.

http://www.wikidata.org/entity/Q36410781

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2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

Enhanced Nrf2 activity worsens ...... osis in leptin-deficient mice.

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Enhanced Nrf2 activity worsens ...... osis in leptin-deficient mice.

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type

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Enhanced Nrf2 activity worsens ...... osis in leptin-deficient mice.

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Enhanced Nrf2 activity worsens ...... osis in leptin-deficient mice.

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Enhanced Nrf2 activity worsens ...... osis in leptin-deficient mice.

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Enhanced Nrf2 activity worsens ...... osis in leptin-deficient mice.

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Enhanced Nrf2 activity worsens ...... tosis in leptin-deficient mice

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Ajay C Donepudi

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Angela L Slitt

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Jialin Xu

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Vijay R More

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P2860

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor

Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity

Adipocytes as regulators of energy balance and glucose homeostasis

PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.

Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity

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3208-3218

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scholarly article

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10.2337/DB11-1716

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12

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61

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Supriya R. Kulkarni

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2012-08-30T00:00:00Z

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230768940

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22936178

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3501889

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