Multiple mRNA species for the precursor to an adenovirus-encoded glycoprotein: identification and structure of the signal sequence
about
Targeting a polyepitope protein incorporating multiple class II-restricted viral epitopes to the secretory/endocytic pathway facilitates immune recognition by CD4+ cytotoxic T lymphocytes: a novel approach to vaccine design.The E3/19K protein of adenovirus type 2 binds to the domains of histocompatibility antigens required for CTL recognition"E3/19K" protein of adenovirus type 2 inhibits lysis of cytolytic T lymphocytes by blocking cell-surface expression of histocompatibility class I antigens.Functions and mechanisms of action of the adenovirus E3 proteins.Endogenously synthesized peptide with an endoplasmic reticulum signal sequence sensitizes antigen processing mutant cells to class I-restricted cell-mediated lysis.Efficient coupled transcription and mRNA splicing in vitro using plasmids derived from early region 3 of adenovirus 2 and a nondefective adenovirus-simian virus 40 hybridAntiangiogenic gene therapy of cancer utilizing a recombinant adenovirus to elevate systemic endostatin levels in mice.Distinct domains in the adenovirus E3 RIDalpha protein are required for degradation of Fas and the epidermal growth factor receptor.The adenovirus E3 14.7-kilodalton protein which inhibits cytolysis by tumor necrosis factor increases the virulence of vaccinia virus in a murine pneumonia model.Characterization of mutants within the gene for the adenovirus E3 14.7-kilodalton protein which prevents cytolysis by tumor necrosis factor.The adenovirus E3 14.5-kilodalton protein, which is required for down-regulation of the epidermal growth factor receptor and prevention of tumor necrosis factor cytolysis, is an integral membrane protein oriented with its C terminus in the cytoplasmA 10,400-molecular-weight membrane protein is coded by region E3 of adenovirusRequirements for the association of adenovirus type 2 E3/19K wild-type and mutant proteins with HLA antigens.Identification and gene mapping of a 14,700-molecular-weight protein encoded by region E3 of group C adenoviruses.Development of a helper-independent human adenovirus vector and its use in the transfer of the herpes simplex virus thymidine kinase gene.An adenovirus mRNA which encodes a 14,700-Mr protein that maps to the last open reading frame of region E3 is expressed during infection.Genetic analysis of mRNA synthesis in adenovirus region E3 at different stages of productive infection by RNA-processing mutantsMapping a new gene that encodes an 11,600-molecular-weight protein in the E3 transcription unit of adenovirus 2Polyadenylic acid addition sites in the adenovirus type 2 major late transcription unit.Early region 1B of adenovirus 2 encodes two coterminal proteins of 495 and 155 amino acid residuesStructures of the oligosaccharides of the glycoprotein coded by early region E3 of adenovirus 2Genomic arrangement of an adenovirus-simian virus 40 hybrid virus, Ad2+ND4del.Purification of a native membrane-associated adenovirus tumor antigenHomology of adenoviral E3 glycoprotein with HLA-DR heavy chain.The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation.Novel deletion mutants that enhance a distant upstream 5' splice in the E3 transcription unit of adenovirus 2.Effect of retroviral endostatin gene transfer on subcutaneous and intraperitoneal growth of murine tumors.The endoplasmic reticulum retention signal of the E3/19K protein of adenovirus type 2 consists of three separate amino acid segments at the carboxy terminus.Immunization with tumor-associated epitopes fused to an endoplasmic reticulum translocation signal sequence affords protection against tumors with down-regulated expression of MHC and peptide transporters.
P2860
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P2860
Multiple mRNA species for the precursor to an adenovirus-encoded glycoprotein: identification and structure of the signal sequence
description
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name
Multiple mRNA species for the ...... ructure of the signal sequence
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Multiple mRNA species for the ...... ructure of the signal sequence
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type
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Multiple mRNA species for the ...... ructure of the signal sequence
@ast
Multiple mRNA species for the ...... ructure of the signal sequence
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Multiple mRNA species for the ...... ructure of the signal sequence
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Multiple mRNA species for the ...... ructure of the signal sequence
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P2093
P2860
P356
P1476
Multiple mRNA species for the ...... ructure of the signal sequence
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P2093
Jörnvall H
Zabielski J
P2860
P304
P356
10.1073/PNAS.77.11.6349
P407
P577
1980-11-01T00:00:00Z