Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life.
about
Mechanisms shaping the naïve T cell repertoire in the elderly - thymic involution or peripheral homeostatic proliferation?Partners in Crime: The Role of CMV in Immune Dysregulation and Clinical Outcome During HIV InfectionImpact of ageing on the response and repertoire of influenza virus-specific CD4 T cells.Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories.The effects of age and cytomegalovirus on markers of inflammation and lymphocyte populations in captive baboonsUnderstanding immunosenescence to improve responses to vaccinesSelf-recognition drives the preferential accumulation of promiscuous CD4(+) T-cells in aged mice.IFNγ⁻TNFα⁻IL2⁻MIP1α⁻CD107a⁺PRF1⁺ CD8 pp65-Specific T-Cell Response Is Independently Associated With Time to Death in Elderly HumansInflammaging decreases adaptive and innate immune responses in mice and humansCMV and Immunosenescence: from basics to clinics.Calorie Restriction Attenuates Terminal Differentiation of Immune Cells.The two faces of heterologous immunity: protection or immunopathology.Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans.The influence of intrinsic and extrinsic factors on immune system agingA population biological approach to understanding the maintenance and loss of the T-cell repertoire during aging.Alloimmunity But Not Viral Immunity Promotes Allograft Loss in a Mouse Model of Polyomavirus-Associated Allograft Injury.CD4+ virtual memory: Antigen-inexperienced T cells reside in the naïve, regulatory, and memory T cell compartments at similar frequencies, implications for autoimmunity.An attenuated temperature-sensitive strain of cytomegalovirus (tsm5) establishes immunity without development of CD8(+) T cell memory inflation.Known unknowns: how might the persistent herpesvirome shape immunity and aging?Cutting Edge: The Aging Immune System Reveals the Biological Impact of Direct Antigen Presentation on CD8 T Cell Responses.Impact of age, sex and CMV-infection on peripheral T cell phenotypes: results from the Berlin BASE-II Study.CMV Primary Infection Is Associated With Donor-Specific T Cell Hyporesponsiveness and Fewer Late Acute Rejections After Liver Transplantation.Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections.Epstein-Barr virus-specific CD8(+) T lymphocytes from diffuse large B cell lymphoma patients are functionally impaired.Gammaherpesvirus latency differentially impacts the generation of primary versus secondary memory CD8+ T cells during subsequent infection.Healthy ageing and depletion of intracellular glutathione influences T cell membrane thioredoxin-1 levels and cytokine secretion.The twilight of immunity: emerging concepts in aging of the immune system.The Contribution of Cytomegalovirus Infection to Immune Senescence Is Set by the Infectious Dose.Tuberculosis in the elderly: Why inflammation matters.A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice.CMV immune evasion and manipulation of the immune system with aging.The impact of inflationary cytomegalovirus-specific memory T cells on anti-tumour immune responses in patients with cancerVirtual memory cells make a major contribution to the response of aged influenza-naïve mice to influenza virus infection
P2860
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P2860
Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Lifelong persistent viral infe ...... T cell immunity in late life.
@ast
Lifelong persistent viral infe ...... T cell immunity in late life.
@en
type
label
Lifelong persistent viral infe ...... T cell immunity in late life.
@ast
Lifelong persistent viral infe ...... T cell immunity in late life.
@en
prefLabel
Lifelong persistent viral infe ...... T cell immunity in late life.
@ast
Lifelong persistent viral infe ...... T cell immunity in late life.
@en
P2860
P50
P356
P1476
Lifelong persistent viral infe ...... T cell immunity in late life.
@en
P2093
Vanessa Venturi
P2860
P304
P356
10.4049/JIMMUNOL.1201867
P407
P577
2012-10-19T00:00:00Z