The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris - Wikidata - awgldk - TriplyDB

The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris

The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris

http://www.wikidata.org/entity/Q36418450

about

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up A lysosome-centered view of nutrient homeostasis TFEB at a glance Transcriptional and epigenetic regulation of autophagy in aging Beyond indigestion: emerging roles for lysosome-based signaling in human disease Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis.TFE3 regulates whole-body energy metabolism in cooperation with TFEB.Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis Zn2+ efflux through lysosomal exocytosis prevents Zn2+-induced toxicity.mTOR and lysosome regulation.Pompe disease: from pathophysiology to therapy and back again MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells.ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function Activation of peroxisome proliferator-activated receptor α induces lysosomal biogenesis in brain cells: implications for lysosomal storage disorders MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5 Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy.Transition metals activate TFEB in overexpressing cells Pompe disease: Shared and unshared features of lysosomal storage disorders Novel Role of TRPML2 in the Regulation of the Innate Immune Response Lysosomal adaptation: How cells respond to lysosomotropic compounds.Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein.Regulation of Liver Metabolism by Autophagy.The awesome lysosome.TFEB and TFE3 are novel components of the integrated stress response.AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes.TFE3 Alleviates Hepatic Steatosis through Autophagy-Induced Lipophagy and PGC1α-Mediated Fatty Acid β-Oxidation.Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway.Identification of modulators of autophagic flux in an image-based high content siRNA screen Molecular regulation of autophagy and its implications for metabolic diseases.Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3.The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages.Degradation and beyond: the macrophage lysosome as a nexus for nutrient sensing and processing in atherosclerosis.Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling Recent insights into the function of autophagy in cancer.Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue

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The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris

http://www.wikidata.org/entity/Q36418450

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2014 nî lūn-bûn

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2014年の論文

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2014年学术文章

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2014年学术文章

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2014年學術文章

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The nutrient-responsive transc ...... d clearance of cellular debris

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The nutrient-responsive transc ...... d clearance of cellular debris

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The nutrient-responsive transc ...... d clearance of cellular debris

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Heba I Diab

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José A Martina

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Li Lishu

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Lim Jeong-A

http://www.w3.org/2001/XMLSchema#string

Nina Raben

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Rosa Puertollano

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Simona Patange

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P2860

Cloning of the gene encoding a novel integral membrane protein, mucolipidin-and identification of the two major founder mutations causing mucolipidosis type IV

Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

Atg101, a novel mammalian autophagy protein interacting with Atg13

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein

Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization

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