gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes.
about
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repairSenataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damageAccumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damagePhospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damageA PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replicationCep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamicsThe Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and RepairA peek into the complex realm of histone phosphorylationExpression and functionality of histone H2A variants in cancerNbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and RepairγH2A binds Brc1 to maintain genome integrity during S-phaseRad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast.Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodelingHCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stabilityTopoisomerase IIalpha controls the decatenation checkpointChemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cellsNumerical analysis of etoposide induced DNA breaksDouble strand break repair functions of histone H2AXRole of mammalian Mre11 in classical and alternative nonhomologous end joiningATR: an essential regulator of genome integrityGammaH2AX and cancerInvolvement of GLTSCR2 in the DNA Damage Response.Adenovirus core protein VII protects the viral genome from a DNA damage response at early times after infection.Dual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V(D)J recombination and T-cell development.Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiationA genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break endsThe annealing helicase SMARCAL1 maintains genome integrity at stalled replication forksA novel and simple micro-irradiation technique for creating localized DNA double-strand breaks.Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombinationHistone variants: emerging players in cancer biology.Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation.Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.Chromatin at the intersection of viral infection and DNA damageFhit loss in lung preneoplasia: relation to DNA damage response checkpoint activation.Identification of the elementary structural units of the DNA damage response.Creating localized DNA double-strand breaks with microirradiation.Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair.
P2860
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P2860
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes.
@ast
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes.
@en
type
label
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes.
@ast
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes.
@en
prefLabel
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes.
@ast
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes.
@en
P1433
P1476
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes.
@en
P2093
Manuel Stucki
P304
P356
10.1016/J.DNAREP.2006.01.012
P577
2006-03-10T00:00:00Z