Treatment with inhibitors of polyamine biosynthesis, which selectively lower intracellular spermine, does not affect the activity of alkylating agents but antagonizes the cytotoxicity of DNA topoisomerase II inhibitors.
about
Effect of polyamine depletion on caspase activation: a study with spermine synthase-deficient cellsThe role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell linesCell penetrating elastin-like polypeptides for therapeutic peptide delivery.Adenovirus-mediated expression of both antisense ODC and AdoMetDC inhibited colorectal cancer cell growth in vitro.Polyamine depletion by ODC-AdoMetDC antisense adenovirus impairs human colorectal cancer growth and invasion in vitro and in vivo.
P2860
Treatment with inhibitors of polyamine biosynthesis, which selectively lower intracellular spermine, does not affect the activity of alkylating agents but antagonizes the cytotoxicity of DNA topoisomerase II inhibitors.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Treatment with inhibitors of p ...... A topoisomerase II inhibitors.
@ast
Treatment with inhibitors of p ...... A topoisomerase II inhibitors.
@en
type
label
Treatment with inhibitors of p ...... A topoisomerase II inhibitors.
@ast
Treatment with inhibitors of p ...... A topoisomerase II inhibitors.
@en
prefLabel
Treatment with inhibitors of p ...... A topoisomerase II inhibitors.
@ast
Treatment with inhibitors of p ...... A topoisomerase II inhibitors.
@en
P2093
P2860
P356
P1476
Treatment with inhibitors of p ...... NA topoisomerase II inhibitors
@en
P2093
E Mascellani
M A Desiderio
P De Feudis
P2860
P2888
P304
P356
10.1038/BJC.1997.176
P407
P577
1997-01-01T00:00:00Z