Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan.
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Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantroneReversion of pH-induced physiological drug resistance: a novel function of copolymeric nanoparticlesDrug resistance and cellular adaptation to tumor acidic pH microenvironmentTumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization.New insights into the kinetic resistance to anticancer agentsCytotoxicity of weak electrolytes after the adaptation of cells to low pH: role of the transmembrane pH gradient.Drug distribution in tumors: mechanisms, role in drug resistance, and methods for modification.The Function of V-ATPases in CancerC-lysine conjugates: pH-controlled light-activated reagents for efficient double-stranded DNA cleavage with implications for cancer therapyAcidic pH reduces VEGF-mediated endothelial cell responses by downregulation of VEGFR-2; relevance for anti-angiogenic therapies.Nanopreparations to overcome multidrug resistance in cancer.Barriers to drug delivery in solid tumors.Involvement of acid-sensing ion channel 1α in hepatic carcinoma cell migration and invasion.Synthesis of new N,N'-bis[1-aryl-3-(piperidine-1-yl)propylidene]hydrazine dihydrochlorides and evaluation of their cytotoxicity against human hepatoma and breast cancer cells.Cancer Chemotherapy Specific to Acidic Nests.Hybrids of amino acids and acetylenic DNA-photocleavers: optimising efficiency and selectivity for cancer phototherapy.Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma.Irinotecan-cisplatin interactions assessed in cell-based screening assays: cytotoxicity, drug accumulation and DNA adduct formation in an NSCLC cell line.Repeated administration of inhibitors for ion pumps reduce markedly tumor growth in vivoExpression of acidosis-dependent genes in human cancer nests.Acidic extracellular microenvironment and cancer.Modulation of growth and radiochemosensitivity of human malignant glioma cells by acidosis.Na+/H+ exchanger activity is increased in doxorubicin-resistant human colon cancer cells and its modulation modifies the sensitivity of the cells to doxorubicin.Metadherin contributes to epithelial-mesenchymal transition and paclitaxel resistance induced by acidic extracellular pH in nasopharyngeal carcinoma.Reversing the undesirable pH-profile of doxorubicin via activation of a di-substituted maleamic acid prodrug at tumor acidity.Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosarcomaExtracellular acidity enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis DR5 in gastric cancer cellsCarbonic anhydrase inhibitors. Selective inhibition of human tumor-associated isozymes IX and XII and cytosolic isozymes I and II with some substituted-2-mercapto-benzenesulfonamidesThe Influence of Metabolism on Drug Response in Cancer
P2860
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P2860
Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan.
@ast
Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan.
@en
type
label
Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan.
@ast
Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan.
@en
prefLabel
Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan.
@ast
Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan.
@en
P2860
P356
P1476
Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan.
@en
P2093
P2860
P2888
P304
P356
10.1038/BJC.1997.201
P407
P577
1997-01-01T00:00:00Z