ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.
about
Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signalingRegulation of extracellular signal-regulated kinase 1/2 influences hippocampal neuronal survival in a rat model of diabetic cerebral ischemiaCellular stress response and innate immune signaling: integrating pathways in host defense and inflammation.Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapiesIntegrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapyHeat shock protein 90α (Hsp90α) is phosphorylated in response to DNA damage and accumulates in repair fociNF-kappaB: a multifaceted transcription factor regulated at several levelsSignals from within: the DNA-damage-induced NF-kappaB responseNFBD1/MDC1 associates with p53 and regulates its function at the crossroad between cell survival and death in response to DNA damageDNA-PK target identification reveals novel links between DNA repair signaling and cytoskeletal regulationSequestration of serum response factor in the hippocampus impairs long-term spatial memoryX-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1)Functional interaction between p90Rsk2 and Emi1 contributes to the metaphase arrest of mouse oocytesPhosphorylation of p50 NF-kappaB at a single serine residue by DNA-dependent protein kinase is critical for VCAM-1 expression upon TNF treatmentNeurokinin-1 receptor antagonist treatment in polymicrobial sepsis: molecular insightsWithaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.Ribosomal protein S6 kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating proteinNuclear initiated NF-κB signaling: NEMO and ATM take center stage.Vimentin and PSF act in concert to regulate IbeA+ E. coli K1 induced activation and nuclear translocation of NF-κB in human brain endothelial cellsA p53 axis regulates B cell receptor-triggered, innate immune system-driven B cell clonal expansion.Metronomic cyclophosphamide activation of anti-tumor immunity: tumor model, mouse host, and drug schedule dependence of gene responses and their upstream regulators.Engagement of Components of DNA-Break Repair Complex and NFκB in Hsp70A1A Transcription Upregulation by Heat Shock.N-acetylcysteine potentiates doxorubicin-induced ATM and p53 activation in ovarian cancer cellsIntracellular survival pathways in the liver.Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expressionAnti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cellsB7-H1 antibodies lose antitumor activity due to activation of p38 MAPK that leads to apoptosis of tumor-reactive CD8(+) T cellsERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence.Analysis of the chemotherapeutic effects of a propadiene compound on malignant ovarian cancer cells.Targeting hyperactivated DNA-PKcs by KU0060648 inhibits glioma progression and enhances temozolomide therapy via suppression of AKT signaling.Beyond ATM: the protein kinase landscape of the DNA damage response.DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species.Logical network of genotoxic stress-induced NF-κB signal transduction predicts putative target structures for therapeutic intervention strategiesPortrait of inflammatory response to ionizing radiation treatment.Immunotherapy Combined with Large Fractions of Radiotherapy: Stereotactic Radiosurgery for Brain Metastases-Implications for Intraoperative Radiotherapy after Resection.Hyperactivation of NF-κB via the MEK signaling is indispensable for the inhibitory effect of cAMP on DNA damage-induced cell death.Oligomannurarate sulfate sensitizes cancer cells to doxorubicin by inhibiting atypical activation of NF-κB via targeting of Mre11.Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase complex in vascular smooth muscle cells.Downregulation of ATM Gene and Protein Expression in Canine Mammary Tumors.
P2860
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P2860
ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
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name
ATM and the catalytic subunit ...... distinct forms of DNA damage.
@ast
ATM and the catalytic subunit ...... distinct forms of DNA damage.
@en
type
label
ATM and the catalytic subunit ...... distinct forms of DNA damage.
@ast
ATM and the catalytic subunit ...... distinct forms of DNA damage.
@en
prefLabel
ATM and the catalytic subunit ...... distinct forms of DNA damage.
@ast
ATM and the catalytic subunit ...... distinct forms of DNA damage.
@en
P2093
P2860
P1476
ATM and the catalytic subunit ...... distinct forms of DNA damage.
@en
P2093
Frank Mercurio
Ganesh R Panta
Lakita G Cavin
Leonard Lothstein
Marcello Arsura
Maria L Cortés
Mervyn Israel
Swayamjot Kaur
Trevor W Sweatman
P2860
P304
P356
10.1128/MCB.24.5.1823-1835.2004
P407
P577
2004-03-01T00:00:00Z