The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis - Wikidata - awgldk - TriplyDB

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

http://www.wikidata.org/entity/Q36423369

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alpha-Synuclein and neuronal cell death Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations Dynamic structural flexibility of α-synuclein Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease Charcot-Marie-Tooth disease and intracellular traffic Novel subcellular localization for α-synuclein: possible functional consequences Function and dysfunction of α-synuclein: probing conformational changes and aggregation by single molecule fluorescence Synucleins antagonize endoplasmic reticulum function to modulate dopamine transporter trafficking Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease Oxidative stress in Alzheimer's and Parkinson's diseases: insights from the yeast Saccharomyces cerevisiae The Synaptic Function of α-Synuclein Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes.Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity More than a Rumor Spreads in Parkinson's Disease Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance Alpha-synuclein spreading in Parkinson's disease Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases Gene-environment interactions: key to unraveling the mystery of Parkinson's disease C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging Role of Rab GTPases in membrane traffic and cell physiology SNCA variant associated with Parkinson disease and plasma alpha-synuclein level.α-Synuclein-induced tubule formation in lipid bilayers Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity.Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models GTPase activity plays a key role in the pathobiology of LRRK2.Context dependent neuroprotective properties of prion protein (PrP).Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans.Two-Pore Channels and Parkinson's Disease: Where's the Link?The transgenic overexpression of alpha-synuclein and not its related pathology associates with complex I inhibition.Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease.Nonaggregated α-synuclein influences SNARE-dependent vesicle docking via membrane binding.

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P2860

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

http://www.wikidata.org/entity/Q36423369

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2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

@ast

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

@en

type

label

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

@ast

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

@en

prefLabel

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

@ast

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

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PNAS.0710685105

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

@en

P2093

Aaron D Gitler

http://www.w3.org/2001/XMLSchema#string

Brooke J Bevis

http://www.w3.org/2001/XMLSchema#string

Charles Barlowe

http://www.w3.org/2001/XMLSchema#string

Guy A Caldwell

http://www.w3.org/2001/XMLSchema#string

J Michael McCaffery

http://www.w3.org/2001/XMLSchema#string

James Shorter

http://www.w3.org/2001/XMLSchema#string

Jean-Christophe Rochet

http://www.w3.org/2001/XMLSchema#string

Katherine E Strathearn

http://www.w3.org/2001/XMLSchema#string

Kim A Caldwell

http://www.w3.org/2001/XMLSchema#string

Linhui Julie Su

http://www.w3.org/2001/XMLSchema#string

P2860

Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity

Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

Alpha-synuclein in Lewy bodies

Coupled ER to Golgi transport reconstituted with purified cytosolic proteins

Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway.

Dual prenylation is required for Rab protein localization and function

Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration

Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

P304

145-150

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scholarly article

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10.1073/PNAS.0710685105

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P433

1

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P478

105

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P50

Susan Lindquist

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2007-12-27T00:00:00Z

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5686098

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P698

18162536

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P921

Parkinson's disease

P932

2224176

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