Laminopathic mutations interfere with the assembly, localization, and dynamics of nuclear lamins.
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Nuclear assembly as a target for anti-cancer therapiesMonoclonal antibodies specific for disease-associated point-mutants: lamin A/C R453W and R482WThe effect of the lamin A and its mutants on nuclear structure, cell proliferation, protein stability, and mobility in embryonic cellsA progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization.Farnesylated nuclear proteins Kugelkern and lamin Dm0 affect nuclear morphology by directly interacting with the nuclear membrane.Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A.Disheveled hair and ear (Dhe), a spontaneous mouse Lmna mutation modeling human laminopathies.Shear stress-induced mechanotransduction protein deregulation and vasculopathy in a mouse model of progeria.Quantitative nucleolar proteomics reveals nuclear re-organization during stress- induced senescence in mouse fibroblast.DNA-damage accumulation and replicative arrest in Hutchinson-Gilford progeria syndromeThe lamin protein family.Lamin A/C mutants disturb sumo1 localization and sumoylation in vitro and in vivo.Reversal of age-dependent nuclear morphology by inhibition of prenylation does not affect lifespan in Caenorhabditis elegansNuclear lamins: major factors in the structural organization and function of the nucleus and chromatinA laminopathic mutation disrupting lamin filament assembly causes disease-like phenotypes in Caenorhabditis elegans.Nuclear lamins: key regulators of nuclear structure and activitiesFission yeast Lem2 and Man1 perform fundamental functions of the animal cell nuclear laminaMechanics of the nucleus.Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphaseAdult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches.Intermediate filaments: primary determinants of cell architecture and plasticity.BAF-1 mobility is regulated by environmental stresses.Broken nuclei--lamins, nuclear mechanics, and disease.Immunohistochemistry on a panel of Emery-Dreifuss muscular dystrophy samples reveals nuclear envelope proteins as inconsistent markers for pathology.The nuclear lamina and heterochromatin: a complex relationship.Nuclear lamina at the crossroads of the cytoplasm and nucleus.NMCP/LINC proteins: putative lamin analogs in plants?Lamina-associated polypeptide (LAP)2α and nucleoplasmic lamins in adult stem cell regulation and disease.Intermediate filaments: a dynamic network that controls cell mechanics.Lamins at the crossroads of mechanosignalingLamins in the nuclear interior - life outside the lamina.Diseases of the Nucleoskeleton.Cell Biology of the Caenorhabditis elegans Nucleus.Global transcriptional changes caused by an EDMD mutation correlate to tissue specific disease phenotypes in C. elegans.Determining nuclear shape: the role of farnesylated nuclear membrane proteins.Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging.Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation.Dynein-pulling forces counteract lamin-mediated nuclear stability during nuclear envelope repair.Invertebrate models of lamin diseases.Prioritization of Variants Detected by Next Generation Sequencing According to the Mutation Tolerance and Mutational Architecture of the Corresponding Genes.
P2860
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P2860
Laminopathic mutations interfere with the assembly, localization, and dynamics of nuclear lamins.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Laminopathic mutations interfe ...... nd dynamics of nuclear lamins.
@ast
Laminopathic mutations interfe ...... nd dynamics of nuclear lamins.
@en
type
label
Laminopathic mutations interfe ...... nd dynamics of nuclear lamins.
@ast
Laminopathic mutations interfe ...... nd dynamics of nuclear lamins.
@en
prefLabel
Laminopathic mutations interfe ...... nd dynamics of nuclear lamins.
@ast
Laminopathic mutations interfe ...... nd dynamics of nuclear lamins.
@en
P2093
P2860
P356
P1476
Laminopathic mutations interfe ...... nd dynamics of nuclear lamins.
@en
P2093
Anna Mattout
Harald Herrmann
Naama Wiesel
Naomi Melamed-Book
Ohad Medalia
Shai Melcer
Yosef Gruenbaum
P2860
P304
P356
10.1073/PNAS.0708974105
P407
P50
P577
2007-12-27T00:00:00Z