Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70 - Wikidata - awgldk - TriplyDB

Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70

Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70

http://www.wikidata.org/entity/Q36429388

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Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks The redox biochemistry of protein sulfenylation and sulfinylation Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.The human HSP70 family of chaperones: where do we stand?Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress Hsp70 Isoforms Are Essential for the Formation of Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Compartments Hsp70-Bag3 interactions regulate cancer-related signaling networks Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau.Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.Collaboration of geldanamycin-activated P70S6K and Hsp70 against beta-amyloid-induced hippocampal apoptosis: an approach to long-term memory and learning An RNA aptamer specific to Hsp70-ATP conformation inhibits its ATPase activity independent of Hsp40.Nontoxic singlet oxygen generator as a therapeutic candidate for treating tauopathies.A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1.Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells Glutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response.The HSP70 family and cancer Identification of Redox and Glucose-Dependent Txnip Protein Interactions Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70 The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules.Role of exercise-induced reactive oxygen species in the modulation of heat shock protein response.Hsp70 in cancer: back to the future.Screening strategies to identify HSP70 modulators to treat Alzheimer's disease.High-throughput screening of cellular redox sensors using modern redox proteomics approaches.Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.Modulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders.Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells.Detection of protein S-sulfhydration by a tag-switch technique.An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56 Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.Chaperone heat shock protein 70 in nucleus accumbens core: a novel biological target of behavioural sensitization to morphine in rats.Evaluation of short- and long-term efficacy of chemoradiotherapy for advanced cervical cancer using HSP70 protein combined with multimodal MRI.N-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione.High Throughput Screen for Inhibitors of Protein-Protein Interactions in a Reconstituted Heat Shock Protein 70 (Hsp70) Complex.Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands?Hsp72 Is an Intracellular Target of the α,β-Unsaturated Sesquiterpene Lactone, Parthenolide.SMYD2 glutathionylation contributes to degradation of sarcomeric proteins

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P2860

Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70

http://www.wikidata.org/entity/Q36429388

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2012 nî lūn-bûn

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Cysteine reactivity distinguis ...... forms of heat shock protein 70

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Cysteine reactivity distinguis ...... forms of heat shock protein 70

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Cysteine reactivity distinguis ...... forms of heat shock protein 70

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Chemistry and Biology

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Cysteine reactivity distinguis ...... forms of heat shock protein 70

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Andrea D Thompson

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Chad A Dickey

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Jason E Gestwicki

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Jennifer N Rauch

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Sharan Srinivasan

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Umesh K Jinwal

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Yoshinari Miyata

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P2860

Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels

Reactive oxygen species: role in the development of cancer and various chronic conditions

Hypoxia-inducible factors and the response to hypoxic stress

Hsp70 chaperones: cellular functions and molecular mechanism

Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

Reactive oxygen species: metabolism, oxidative stress, and signal transduction

Molecular chaperones in protein folding and proteostasis

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