Targeting GSK-3: a promising approach for cancer therapy?
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Therapeutic Implications of Targeting AKT Signaling in MelanomaGlycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and ImagingGSK3β signaling is involved in ultraviolet B-induced activation of autophagy in epidermal cellsA New alpha5beta1 integrin-dependent survival pathway through GSK3beta activation in leukemic cellsPoint mutations in the tumor suppressor Smad4/DPC4 enhance its phosphorylation by GSK3 and reversibly inactivate TGF-β signalingPrimers on molecular pathways. The glycogen synthase kinase-3betaGenetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistanceGlycogen synthase kinase-3 inhibition disrupts nuclear factor-kappaB activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapyA novel role for GSK3β as a modulator of Drosha microprocessor activity and MicroRNA biogenesisIdentification of glycogen synthase kinase 3α as a therapeutic target in melanomaBiological basis and clinical study of glycogen synthase kinase- 3β-targeted therapy by drug repositioning for glioblastoma.Striking the target in Wnt-y conditions: intervening in Wnt signaling during cancer progressionDeregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3β activation in young miceConcerted suppression of STAT3 and GSK3β is involved in growth inhibition of non-small cell lung cancer by Xanthatin.Functions of GSK-3 Signaling in Development of the Nervous System.Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferationMiR-375 promotes redifferentiation of adult human β cells expanded in vitroGlycogen synthase kinase-3β promotes cyst expansion in polycystic kidney diseaseWater extract of brewers' rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/β-catenin downstream signaling pathway in brewers' rice-treated rats with azoxymethane-induced coloIdentification of Wnt/β-catenin modulated genes in the developing retina.Glycogen synthase kinase-3 inhibitor AR-A014418 suppresses pancreatic cancer cell growth via inhibition of GSK-3-mediated Notch1 expression.Docosahexaenoic acid (DHA) and hepatic gene transcriptionChemoprevention of lung tumorigenesis by intranasally administered diindolylmethane in A/J mice.Nonclassical activation of Hedgehog signaling enhances multidrug resistance and makes cancer cells refractory to Smoothened-targeting Hedgehog inhibitionGrowth control of multiple myeloma cells through inhibition of glycogen synthase kinase-3Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy.Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period.Inhibiting glycogen synthase kinase-3 reduces endotoxaemic acute renal failure by down-regulating inflammation and renal cell apoptosis.The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma.Scientific Evidence of Rice By-Products for Cancer Prevention: Chemopreventive Properties of Waste Products from Rice Milling on Carcinogenesis In Vitro and In Vivo.Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells.NLS‑RARα modulates acute promyelocytic leukemia NB4 cell proliferation and differentiation via the PI3K/AKT pathway.The potential dual effects of sevoflurane on AKT/GSK3β signaling pathwayGlycogen synthase kinase-3beta regulates astrocytic differentiation of U87-MG human glioblastoma cellsGambogic acid inhibits TNF-α-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-κB signaling pathways.Glycogen synthase kinase 3 beta: can it be a target for oral cancer.Cross-Regulation Between Wnt and NF-κB Signaling Pathways.Glycogen Synthase Kinase 3β in Pancreatic Cancer and its Implications in Chemotherapy and Radiation Therapy.Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases
P2860
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P2860
Targeting GSK-3: a promising approach for cancer therapy?
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
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2006年學術文章
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name
Targeting GSK-3: a promising approach for cancer therapy?
@ast
Targeting GSK-3: a promising approach for cancer therapy?
@en
type
label
Targeting GSK-3: a promising approach for cancer therapy?
@ast
Targeting GSK-3: a promising approach for cancer therapy?
@en
prefLabel
Targeting GSK-3: a promising approach for cancer therapy?
@ast
Targeting GSK-3: a promising approach for cancer therapy?
@en
P2860
P356
P1433
P1476
Targeting GSK-3: a promising approach for cancer therapy?
@en
P2093
Andrei V Ougolkov
Daniel D Billadeau
P2860
P304
P356
10.2217/14796694.2.1.91
P407
P577
2006-02-01T00:00:00Z