Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).
about
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancerStructurally diverse low molecular weight activators of the mammalian pre-mRNA 3' cleavage reactionWIP1 phosphatase as pharmacological target in cancer therapy.Cyclic peptides as therapeutic agents and biochemical tools.WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C.Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesisBinding of a third metal ion by the human phosphatases PP2Cα and Wip1 is required for phosphatase activityInhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3.WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function.
P2860
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P2860
Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).
description
2011 nî lūn-bûn
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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name
Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).
@ast
Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).
@en
type
label
Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).
@ast
Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).
@en
prefLabel
Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).
@ast
Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).
@en
P2093
P2860
P356
P1433
P1476
Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).
@en
P2093
Daniel H Appella
Deb K Chatterjee
Ettore Appella
Kan Tanoue
Lisa M Miller Jenkins
Ryo Hayashi
Stewart R Durell
P2860
P304
P356
10.1021/BI101949T
P407
P577
2011-05-09T00:00:00Z