The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes.
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Insulin stimulates translocation of human GLUT4 to the membrane in fat bodies of transgenic Drosophila melanogasterExpression and phosphorylation of the AS160_v2 splice variant supports GLUT4 activation and the Warburg effect in multiple myeloma.Roles of TBC1D1 and TBC1D4 in insulin- and exercise-stimulated glucose transport of skeletal muscleSelective insulin resistance in adipocytesA Triterpenoid Inhibited Hormone-Induced Adipocyte Differentiation and Alleviated Dexamethasone-Induced Insulin Resistance in 3T3-L1 adipocytes.E4orf1 induction in adipose tissue promotes insulin-independent signaling in the adipocyte.The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors.Mechanisms for greater insulin-stimulated glucose uptake in normal and insulin-resistant skeletal muscle after acute exercise.Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action.CD4 memory T cells develop and acquire functional competence by sequential cognate interactions and stepwise gene regulationInsulin-induced Effects on the Subcellular Localization of AKT1, AKT2 and AS160 in Rat Skeletal Muscle.Inhibition of Akt2 phosphorylation abolishes the calorie restriction-induced improvement in insulin-stimulated glucose uptake by rat soleus muscle.Glut4 Is Sorted from a Rab10 GTPase-independent Constitutive Recycling Pathway into a Highly Insulin-responsive Rab10 GTPase-dependent Sequestration Pathway after Adipocyte Differentiation.Molecular adaptations of adipose tissue to 6 weeks of morning fasting vs. daily breakfast consumption in lean and obese adults.Natriuretic peptides promote glucose uptake in a cGMP-dependent manner in human adipocytes.The carboxy-terminal region of the TBC1D4 (AS160) RabGAP mediates protein homodimerization.Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases.Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity
P2860
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P2860
The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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2012年學術文章
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2012年學術文章
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name
The Rab GTPase-activating prot ...... UT4 trafficking in adipocytes.
@ast
The Rab GTPase-activating prot ...... UT4 trafficking in adipocytes.
@en
type
label
The Rab GTPase-activating prot ...... UT4 trafficking in adipocytes.
@ast
The Rab GTPase-activating prot ...... UT4 trafficking in adipocytes.
@en
prefLabel
The Rab GTPase-activating prot ...... UT4 trafficking in adipocytes.
@ast
The Rab GTPase-activating prot ...... UT4 trafficking in adipocytes.
@en
P2093
P2860
P50
P356
P1476
The Rab GTPase-activating prot ...... UT4 trafficking in adipocytes.
@en
P2093
David G Lambright
Jacqueline Stöckli
Shi-Xiong Tan
P2860
P304
P356
10.1128/MCB.00761-12
P407
P577
2012-10-08T00:00:00Z