A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence.
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Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and LidocaineA molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channelExploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics.Comparative study of the gating motif and C-type inactivation in prokaryotic voltage-gated sodium channels.Two components of voltage-dependent inactivation in Ca(v)1.2 channels revealed by its gating currents.Tryptophan scanning of D1S6 and D4S6 C-termini in voltage-gated sodium channelsA sodium channel pore mutation causing Brugada syndromeSubunit dependence of Na channel slow inactivation and open channel block in cerebellar neuronsGating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor.Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door?Sodium channel inactivation: molecular determinants and modulation.Molecular action of lidocaine on the voltage sensors of sodium channelsSlow inactivation does not block the aqueous accessibility to the outer pore of voltage-gated Na channels.Molecular motions of the outer ring of charge of the sodium channel: do they couple to slow inactivation?Channel openings are necessary but not sufficient for use-dependent block of cardiac Na(+) channels by flecainide: evidence from the analysis of disease-linked mutations.Proton sensors in the pore domain of the cardiac voltage-gated sodium channel.Effect of amitriptyline on tetrodotoxin-resistant Nav1.9 currents in nociceptive trigeminal neurons.Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in immature cerebrocortical neurons.Novel molecular determinants in the pore region of sodium channels regulate local anesthetic binding.The outer vestibule of the Na+ channel-toxin receptor and modulator of permeation as well as gating.Lidocaine reduces the transition to slow inactivation in Na(v)1.7 voltage-gated sodium channels.Identification of sodium channel isoforms that mediate action potential firing in lamina I/II spinal cord neurons.Isoflurane modulates activation and inactivation gating of the prokaryotic Na+ channel NaChBac.The sodium channel as a target for local anesthetic drugs.Functional Interactions between Distinct Sodium Channel Cytoplasmic Domains through the Action of Calmodulin.Relative resistance to slow inactivation of human cardiac Na+ channel hNav1.5 is reversed by lysine or glutamine substitution at V930 in D2-S6.The pore, not cytoplasmic domains, underlies inactivation in a prokaryotic sodium channel.Comparison of aconitine-modified human heart (hH1) and rat skeletal (mu1) muscle Na+ channels: an important role for external Na+ ions.Interaction of scorpion alpha-toxins with cardiac sodium channels: binding properties and enhancement of slow inactivation.A thermosensitive mutation alters the effects of lacosamide on slow inactivation in neuronal voltage-gated sodium channels, NaV1.2.The selectivity filter of the voltage-gated sodium channel is involved in channel activation.Negatively charged residues adjacent to IFM motif in the DIII-DIV linker of hNa(V)1.4 differentially affect slow inactivation.Compound-specific Na+ channel pore conformational changes induced by local anaesthetics.A naturally occurring amino acid substitution in the voltage-dependent sodium channel selectivity filter affects channel gating.Similar properties of transient, persistent, and resurgent Na currents in GABAergic and non-GABAergic vestibular nucleus neurons.Mechanisms of Drug Binding to Voltage-Gated Sodium Channels.Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective.A conserved ring of charge in mammalian Na+ channels: a molecular regulator of the outer pore conformation during slow inactivation.
P2860
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P2860
A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
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2000年學術文章
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name
A structural rearrangement in ...... activation and use dependence.
@ast
A structural rearrangement in ...... activation and use dependence.
@en
type
label
A structural rearrangement in ...... activation and use dependence.
@ast
A structural rearrangement in ...... activation and use dependence.
@en
prefLabel
A structural rearrangement in ...... activation and use dependence.
@ast
A structural rearrangement in ...... activation and use dependence.
@en
P2093
P2860
P356
P1476
A structural rearrangement in ...... activation and use dependence.
@en
P2093
G F Tomaselli
J R Balser
P2860
P304
P356
10.1085/JGP.116.5.653
P577
2000-11-01T00:00:00Z