Movement of voltage sensor S4 in domain 4 is tightly coupled to sodium channel fast inactivation and gating charge immobilization
about
Neuronal sodium-channel alpha1-subunit mutations in generalized epilepsy with febrile seizures plus.Single-channel properties of human NaV1.1 and mechanism of channel dysfunction in SCN1A-associated epilepsyThe hitchhiker's guide to the voltage-gated sodium channel galaxyAltered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalitiesStudies of alpha-helicity and intersegmental interactions in voltage-gated Na+ channels: S2D4.Sodium channel carboxyl-terminal residue regulates fast inactivation.Variable ratio of permeability to gating charge of rBIIA sodium channels and sodium influx in Xenopus oocytes.The outermost lysine in the S4 of domain III contributes little to the gating charge in sodium channels.Modulation of neuronal sodium channels by the sea anemone peptide BDS-I.Genetic analysis of a synaptic calcium channel in Drosophila: intragenic modifiers of a temperature-sensitive paralytic mutant of cacophonyAlpha-scorpion toxin impairs a conformational change that leads to fast inactivation of muscle sodium channels.Voltage-dependent displacement of the scorpion toxin Ts3 from sodium channels and its implication on the control of inactivationDirect evidence that scorpion α-toxins (site-3) modulate sodium channel inactivation by hindrance of voltage-sensor movementsSequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels.Defective fast inactivation recovery of Nav 1.4 in congenital myasthenic syndrome.Charge immobilization of skeletal muscle Na+ channels: role of residues in the inactivation linkerSodium channel inactivation: molecular determinants and modulation.The role of the putative inactivation lid in sodium channel gating current immobilizationRole of domain 4 in sodium channel slow inactivationSite-3 toxins and cardiac sodium channels.Lidocaine-induced Brugada syndrome phenotype linked to a novel double mutation in the cardiac sodium channel.Extracellular protons inhibit charge immobilization in the cardiac voltage-gated sodium channel.Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels.A gating charge interaction required for late slow inactivation of the bacterial sodium channel NavAb.The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na(+) channelSkeletal muscle na channel disorders.Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes.Multiple targets for flecainide action: implications for cardiac arrhythmogenesis.Outer and central charged residues in DIVS4 of skeletal muscle sodium channels have differing roles in deactivation.Gating of the expressed Cav3.1 calcium channel.More gating charges are needed to open a Shaker K+ channel than are needed to open an rBIIA Na+ channel.A sodium channel mutation causing epilepsy in man exhibits subtle defects in fast inactivation and activation in vitro.Open- and closed-state fast inactivation in sodium channels: differential effects of a site-3 anemone toxin.Reduced voltage dependence of inactivation in the SCN5A sodium channel mutation delF1617.Solution structures of the cytoplasmic linkers between segments S4 and S5 (S4-S5) in domains III and IV of human brain sodium channels in SDS micelles.Negatively charged residues adjacent to IFM motif in the DIII-DIV linker of hNa(V)1.4 differentially affect slow inactivation.Outward stabilization of the voltage sensor in domain II but not domain I speeds inactivation of voltage-gated sodium channels.Consequence of the presence of two different beta subunit isoforms in a GABA(A) receptor.A perspective on Na and K channel inactivation.Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective.
P2860
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P2860
Movement of voltage sensor S4 in domain 4 is tightly coupled to sodium channel fast inactivation and gating charge immobilization
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Movement of voltage sensor S4 ...... d gating charge immobilization
@ast
Movement of voltage sensor S4 ...... d gating charge immobilization
@en
type
label
Movement of voltage sensor S4 ...... d gating charge immobilization
@ast
Movement of voltage sensor S4 ...... d gating charge immobilization
@en
prefLabel
Movement of voltage sensor S4 ...... d gating charge immobilization
@ast
Movement of voltage sensor S4 ...... d gating charge immobilization
@en
P2860
P356
P1476
Movement of voltage sensor S4 ...... d gating charge immobilization
@en
P2093
P2860
P304
P356
10.1085/JGP.114.2.167
P577
1999-08-01T00:00:00Z