Cytochrome P450s and other enzymes in drug metabolism and toxicity. - Wikidata - awgldk - TriplyDB

Cytochrome P450s and other enzymes in drug metabolism and toxicity.

Cytochrome P450s and other enzymes in drug metabolism and toxicity.

http://www.wikidata.org/entity/Q36439150

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Toxic hepatitis in occupational exposure to solvents CYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysis Arachidonic acid monooxygenase: Genetic and biochemical approaches to physiological/pathophysiological relevance Regulation of Drosophila metamorphosis by xenobiotic response regulators Systematic identification and evolutionary analysis of catalytically versatile cytochrome p450 monooxygenase families enriched in model basidiomycete fungi The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY Patient counseling about herbal-drug interactions.Cytochrome P450 site of metabolism prediction from 2D topological fingerprints using GPU accelerated probabilistic classifiers Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations P450 monooxygenases (P450ome) of the model white rot fungus Phanerochaete chrysosporium Multiple roles of Nrf2-Keap1 signaling: regulation of development and xenobiotic response using distinct mechanisms Linear Interaction Energy Based Prediction of Cytochrome P450 1A2 Binding Affinities with Reliability Estimation Metabolic enzyme microarray coupled with miniaturized cell-culture array technology for high-throughput toxicity screening Aflatoxin B1 metabolism RS-Predictor models augmented with SMARTCyp reactivities: robust metabolic regioselectivity predictions for nine CYP isozymes.A model of the membrane-bound cytochrome b5-cytochrome P450 complex from NMR and mutagenesis data.Extending P450 site-of-metabolism models with region-resolution data.Novel Uses of In Vitro Data to Develop Quantitative Biological Activity Relationship Models for in Vivo Carcinogenicity Prediction.CYP3A4 overexpression enhances apoptosis induced by anticancer agent imidazoacridinone C-1311, but does not change the metabolism of C-1311 in CHO cells.CYP2C9-CYP3A4 protein-protein interactions: role of the hydrophobic N terminus.Regulation of human CYP2C9 expression by electrophilic stress involves activator protein 1 activation and DNA looping.Computational and in vitro studies on the inhibitory effects of herbal compounds on human cytochrome P450 1A2.High-throughput and combinatorial gene expression on a chip for metabolism-induced toxicology screening.Multiple-approaches to the identification and quantification of cytochromes P450 in human liver tissue by mass spectrometry.Bimodal targeting of microsomal cytochrome P450s to mitochondria: implications in drug metabolism and toxicity Characterization of 107 genomic DNA reference materials for CYP2D6, CYP2C19, CYP2C9, VKORC1, and UGT1A1: a GeT-RM and Association for Molecular Pathology collaborative project.Evaluation of metabolism-mediated herb-drug interactions.Safety and tolerability of antiepileptic drug treatment in children with epilepsy.The Simplest Flowchart Stating the Mechanisms for Organic Xenobiotics-induced Toxicity: Can it Possibly be Accepted as a "Central Dogma" for Toxic Mechanisms?The pathway ontology - updates and applications.Cytochrome P450 single nucleotide polymorphisms in an indigenous Tanzanian population: a concern about the metabolism of artemisinin-based combinations.Synthetic studies of neoclerodane diterpenes from Salvia divinorum: role of the furan in affinity for opioid receptors Metabolic pathways of the camptothecin analog AR-67 Psychiatric treatment considerations with direct acting antivirals in hepatitis C WhichCyp: prediction of cytochromes P450 inhibition.Indolealkylamines: biotransformations and potential drug-drug interactions Active-site residues move independently from the rest of the protein in a 200 ns molecular dynamics simulation of cytochrome P450 CYP119.Methodology to assay CYP2E1 mixed function oxidase catalytic activity and its induction Molecular mechanisms of the microsomal mixed function oxidases and biological and pathological implications

P2860

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P2860

Cytochrome P450s and other enzymes in drug metabolism and toxicity.

http://www.wikidata.org/entity/Q36439150

description

2006 nî lūn-bûn

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2006年の論文

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年學術文章

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2006年學術文章

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2006年學術文章

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name

Cytochrome P450s and other enzymes in drug metabolism and toxicity.

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Cytochrome P450s and other enzymes in drug metabolism and toxicity.

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type

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Cytochrome P450s and other enzymes in drug metabolism and toxicity.

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Cytochrome P450s and other enzymes in drug metabolism and toxicity.

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Cytochrome P450s and other enzymes in drug metabolism and toxicity.

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Cytochrome P450s and other enzymes in drug metabolism and toxicity.

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The AAPS Journal

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Cytochrome P450s and other enzymes in drug metabolism and toxicity.

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F Peter Guengerich

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P2860

Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase

Clinical importance of the cytochromes P450

Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage

Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene

Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases

Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions

Reaction of aflatoxin B(1) oxidation products with lysine

Predicting in vivo drug interactions from in vitro drug discovery data.

Reaction of trichloroethylene oxide with proteins and dna: instability of adducts and modulation of functions.

Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry.

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10.1208/AAPSJ080112

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1

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8

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2751428

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