Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models
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Pharmacogenetics of BCR/ABL Inhibitors in Chronic Myeloid LeukemiaMolecular modeling and docking of small molecule inhibitors against NEK2Recent advances regarding the role of ABC subfamily C member 10 (ABCC10) in the efflux of antitumor drugs.Pharmacophore modeling of nilotinib as an inhibitor of ATP-binding cassette drug transporters and BCR-ABL kinase using a three-dimensional quantitative structure-activity relationship approachLamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells.Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2.Reversal of MRP7 (ABCC10)-mediated multidrug resistance by tariquidar.Repositioning of Tyrosine Kinase Inhibitors as Antagonists of ATP-Binding Cassette Transporters in Anticancer Drug ResistanceIn vitro, in vivo and ex vivo characterization of ibrutinib: a potent inhibitor of the efflux function of the transporter MRP1.WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells.ABC transporters in multi-drug resistance and ADME-Tox of small molecule tyrosine kinase inhibitors.The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study.Overlapping functions of ABC transporters in topotecan disposition as determined in gene knockout mouse models.Design, synthesis, and biological evaluation of (S)-valine thiazole-derived cyclic and noncyclic peptidomimetic oligomers as modulators of human P-glycoprotein (ABCB1).Drug Resistance Mechanisms in Non-Small Cell Lung Carcinoma.Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated paclitaxel resistance: a preclinical study.Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna) with the human ABC drug transporter P-glycoprotein.Alectinib (CH5424802) antagonizes ABCB1- and ABCG2-mediated multidrug resistance in vitro, in vivo and ex vivoTyrosine kinase inhibitors as reversal agents for ABC transporter mediated drug resistance.Ponatinib enhances anticancer drug sensitivity in MRP7-overexpressing cells.Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivoModulating the function of ATP-binding cassette subfamily G member 2 (ABCG2) with inhibitor cabozantinib.A preclinical study demonstrating the efficacy of nilotinib in inhibiting the growth of pediatric high-grade glioma.Pharmacokinetic drug-drug interactions of tyrosine kinase inhibitors: A focus on cytochrome P450, transporters, and acid suppression therapy.PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells.Tandutinib (MLN518) reverses multidrug resistance by inhibiting the efflux activity of the multidrug resistance protein 7 (ABCC10).Tea nanoparticle, a safe and biocompatible nanocarrier, greatly potentiates the anticancer activity of doxorubicin.The hOCT1 and ABCB1 polymorphisms do not influence the pharmacodynamics of nilotinib in chronic myeloid leukemia.Differential effects of c-myc and ABCB1 silencing on reversing drug resistance in HepG2/Dox cells.Quizartinib (AC220) reverses ABCG2-mediated multidrug resistance: In vitro and in vivo studies.The National Cancer Institute ALMANAC: A Comprehensive Screening Resource for the Detection of Anticancer Drug Pairs with Enhanced Therapeutic Activity.OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity.Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells.TKI combination therapy: strategy to enhance dasatinib uptake by inhibiting Pgp- and BCRP-mediated efflux.Bax/Tubulin/Epithelial-Mesenchymal Pathways Determine the Efficacy of Silybin Analog HM015k in Colorectal Cancer Cell Growth and Metastasis.Cariprazine, A Dopamine D₂/D₃ Receptor Partial Agonist, Modulates ABCG2-Mediated Multidrug Resistance in Cancer
P2860
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P2860
Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Nilotinib potentiates anticanc ...... ug resistance xenograft models
@ast
Nilotinib potentiates anticanc ...... ug resistance xenograft models
@en
type
label
Nilotinib potentiates anticanc ...... ug resistance xenograft models
@ast
Nilotinib potentiates anticanc ...... ug resistance xenograft models
@en
prefLabel
Nilotinib potentiates anticanc ...... ug resistance xenograft models
@ast
Nilotinib potentiates anticanc ...... ug resistance xenograft models
@en
P2093
P2860
P1433
P1476
Nilotinib potentiates anticanc ...... ug resistance xenograft models
@en
P2093
Alaa H Abuznait
Amal Kaddoumi
Amit K Tiwari
Chun-Ling Dai
James M Gallo
Kamlesh Sodani
Tanaji T Talele
Zhe-Sheng Chen
Zhi-Jie Xiao
P2860
P304
P356
10.1016/J.CANLET.2012.10.001
P407
P577
2012-10-09T00:00:00Z