Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq. - Wikidata - awgldk - TriplyDB

Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq.

Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq.

http://www.wikidata.org/entity/Q36446199

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Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants Erythro-megakaryocytic transcription factors associated with hereditary anemia Prediction of novel long non-coding RNAs based on RNA-Seq data of mouse Klf1 knockout study.Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation.Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche.Krüppel-like factors compete for promoters and enhancers to fine-tune transcription.KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation.Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome.Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis.Development and differentiation of the erythroid lineage in mammals The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts.Robust hematopoietic progenitor cell commitment in the presence of a conflicting cue The DEK Oncoprotein Is a Critical Component of the EKLF/KLF1 Enhancer in Erythroid Cells.Distinct gene expression program dynamics during erythropoiesis from human induced pluripotent stem cells compared with adult and cord blood progenitors.Simvastatin and t-butylhydroquinone suppress KLF1 and BCL11A gene expression and additively increase fetal hemoglobin in primary human erythroid cells Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation.DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor Ldb1 complexes: the new master regulators of erythroid gene transcription.Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation.Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development.EKLF/KLF1, a tissue-restricted integrator of transcriptional control, chromatin remodeling, and lineage determination.Mechanisms and proteins involved in long-distance interactions.Hematopoietic transcriptional mechanisms: from locus-specific to genome-wide vantage points.The erythroblastic island as an emerging paradigm in the anemia of inflammation.Direct targets of pSTAT5 signalling in erythropoiesis.Epo reprograms the epigenome of erythroid cells.Orchestration of late events in erythropoiesis by KLF1/EKLF.Long non-coding RNAs control hematopoietic stem cell function.Deficiency in interferon type 1 receptor improves definitive erythropoiesis in Klf1 null mice.Mutant KLF1 in Adult Anemic Nan Mice Leads to Profound Transcriptome Changes and Disordered Erythropoiesis

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Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq.

http://www.wikidata.org/entity/Q36446199

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2012 nî lūn-bûn

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2012年学术文章

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name

Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq.

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Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq.

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type

label

Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq.

@ast

Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq.

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prefLabel

Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq.

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Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq.

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Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq.

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Andrew C Perkins

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Evgeny A Glazov

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Graham W Magor

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Jessica M Fittock

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Lei Sun

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Michael R Tallack

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Stephen Huang

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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences

Caspase activation is required for terminal erythroid differentiation

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

A dominant mutation in the gene encoding the erythroid transcription factor KLF1 causes a congenital dyserythropoietic anemia

Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1

Functional cross-antagonism between transcription factors FLI-1 and EKLF

A gene atlas of the mouse and human protein-encoding transcriptomes

Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF)

A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins

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2385-2398

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10.1101/GR.135707.111

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12

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230572631

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T cell acute lymphocytic leukemia 1

GATA binding protein 1

Krueppel-like factor 1

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3514668

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