Slicing a protease: structural features of the ATP-dependent Lon proteases gleaned from investigations of isolated domains.
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The AAA+ superfamily of functionally diverse proteinsArmand-Frappier outstanding student award -- role of ATP-dependent proteases in antibiotic resistance and virulenceEvolution and significance of the Lon gene family in Arabidopsis organelle biogenesis and energy metabolismDetermination of protein structures--a series of fortunate events.Structure of the N-terminal fragment ofEscherichia coliLon proteaseCrystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamberStructures of an ATP-independent Lon-like protease and its complexes with covalent inhibitorsThe N-terminal substrate-recognition domain of a LonC protease exhibits structural and functional similarity to cytosolic chaperonesStructural basis for DNA-mediated allosteric regulation facilitated by the AAA+ module of Lon proteaseThe Lon protease is essential for full virulence in Pseudomonas aeruginosaInvolvement of an ATP-dependent protease, PA0779/AsrA, in inducing heat shock in response to tobramycin in Pseudomonas aeruginosaThe N-terminal domain plays a crucial role in the structure of a full-length human mitochondrial Lon protease.LocateP: genome-scale subcellular-location predictor for bacterial proteins.Novel conserved group A streptococcal proteins identified by the antigenome technology as vaccine candidates for a non-M protein-based vaccine.Local and global mobility in the ClpA AAA+ chaperone detected by cryo-electron microscopy: functional connotations.Lon protease quality control of presecretory proteins in Escherichia coli and its dependence on the SecB and DnaJ (Hsp40) chaperones.Mitochondrial Lon protease at the crossroads of oxidative stress, ageing and cancer.Functional mechanics of the ATP-dependent Lon protease- lessons from endogenous protein and synthetic peptide substrates.Degrons in protein substrates program the speed and operating efficiency of the AAA+ Lon proteolytic machine.A mutation in the N domain of Escherichia coli lon stabilizes dodecamers and selectively alters degradation of model substrates.Utilization of positional isotope exchange experiments to evaluate reversibility of ATP hydrolysis catalyzed by Escherichia coli Lon protease.The multifaceted role of Lon proteolysis in seedling establishment and maintenance of plant organelle function: living from protein destruction.Structural basis for the ATP-independent proteolytic activity of LonB proteases and reclassification of their AAA+ modules.The role of Lon-mediated proteolysis in the dynamics of mitochondrial nucleic acid-protein complexes.Crystallization and preliminary X-ray crystallographic analysis of Lon from Thermococcus onnurineus NA1.Polyphosphate, cyclic AMP, guanosine tetraphosphate, and c-di-GMP reduce in vitro Lon activity.Lon protease affects the RdxA nitroreductase activity and metronidazole susceptibility in Helicobacter pylori.Stress-induced Oryza sativa RuvBL1a is DNA-independent ATPase and unwinds DNA duplex in 3' to 5' direction.A redox switch shapes the Lon protease exit pore to facultatively regulate proteolysisMultiple domains of bacterial and human Lon proteases define substrate selectivity
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P2860
Slicing a protease: structural features of the ATP-dependent Lon proteases gleaned from investigations of isolated domains.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Slicing a protease: structural ...... tigations of isolated domains.
@ast
Slicing a protease: structural ...... tigations of isolated domains.
@en
type
label
Slicing a protease: structural ...... tigations of isolated domains.
@ast
Slicing a protease: structural ...... tigations of isolated domains.
@en
prefLabel
Slicing a protease: structural ...... tigations of isolated domains.
@ast
Slicing a protease: structural ...... tigations of isolated domains.
@en
P2093
P2860
P356
P1433
P1476
Slicing a protease: structural ...... tigations of isolated domains.
@en
P2093
Alexander Wlodawer
Alla Gustchina
Edward E Melnikov
Fatima Rasulova
Istvan Botos
Michael R Maurizi
Tatyana V Rotanova
P2860
P304
P356
10.1110/PS.052069306
P577
2006-08-01T00:00:00Z