Preclinical development of new drugs that enhance thyroid hormone metabolism and clearance: inadequacy of using rats as an animal model for predicting human risks in an IND and NDA.
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Effects of hepatic drug-metabolizing enzyme induction on clinical pathology parameters in animals and man.Effect of soy isoflavones on thyroid hormones in intact and ovariectomized cynomolgus monkeys (Macaca fascicularis).The effects of cytochrome P450 induction by xenobiotics on endobiotic metabolism in pre-clinical safety studies.Extrapolation of hypothalamic-pituitary-thyroid axis perturbations and associated toxicity in rodents to humans: case study with perchlorate.Mammalian toxicology and human exposures to the flame retardant 2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol (TBBPA): implications for risk assessment.Regulatory Forum commentary: alternative mouse models for future cancer risk assessment.Timing of carcinogenicity studies and predictability of genotoxicity for tumorigenicity in anti-HIV drug development.Characterization of xenobiotic-induced hepatocellular enzyme induction in rats: anticipated thyroid effects and unique pituitary gland findings.
P2860
Q33618803-73AC386A-28F8-432C-BAE8-2E8342A6D075Q34161048-3E72B327-9763-455C-81F4-94F26677ACFCQ37706625-026ED126-5200-4F4A-A803-719665E5D537Q37998160-66800BC7-DDC8-47E0-9690-16F1102C4C2AQ38172406-C23C6786-D4D2-4A16-99AC-6AC3316BDA74Q39363493-1A3E0B94-2323-4302-9BB1-93903FB26AC4Q47822520-31722CF7-C767-4979-B0BB-EE34B12A2AEEQ51466740-C27D22A8-68F2-4A8B-8F50-6272F82462E6
P2860
Preclinical development of new drugs that enhance thyroid hormone metabolism and clearance: inadequacy of using rats as an animal model for predicting human risks in an IND and NDA.
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2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
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2006年學術文章
@zh-hant
name
Preclinical development of new ...... human risks in an IND and NDA.
@ast
Preclinical development of new ...... human risks in an IND and NDA.
@en
type
label
Preclinical development of new ...... human risks in an IND and NDA.
@ast
Preclinical development of new ...... human risks in an IND and NDA.
@en
prefLabel
Preclinical development of new ...... human risks in an IND and NDA.
@ast
Preclinical development of new ...... human risks in an IND and NDA.
@en
P1476
Preclinical development of new ...... human risks in an IND and NDA.
@en
P2093
James G Farrelly
Kuei-Meng Wu
P304
P356
10.1097/01.MJT.0000209673.01885.B0
P577
2006-03-01T00:00:00Z