Scientific perspectives on drug transporters and their role in drug interactions.
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Membrane transporters in drug developmentP-glycoprotein inhibition increases the brain distribution and antidepressant-like activity of escitalopram in rodentsOCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.Impaired heat shock response in cells expressing full-length polyglutamine-expanded huntingtin.Role of P glycoprotein in absorption of novel antimalarial drugs.Functional xenobiotic metabolism and efflux transporters in trout hepatocyte spheroid cultures.The physiological role of drug transporters.Interactions between antidepressants and P-glycoprotein at the blood-brain barrier: clinical significance of in vitro and in vivo findings.Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of in-vitro liver technologies.Differential expression of several drug transporter genes in HepG2 and Huh-7 cell lines.Transporter-mediated drug interactions: clinical implications and in vitro assessment.New era in drug interaction evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process.Interactions between tenofovir and nevirapine in CD4+ T cells and monocyte-derived macrophages restrict their intracellular accumulation.Pharmacokinetics and dose recommendations for cyclosporine and tacrolimus when coadministered with ABT-450, ombitasvir, and dasabuvirDrug metabolism and pharmacokinetics.Organic anion-transporting polypeptides.Interactions between herbal remedies and medicinal drugs--considerations about Cuba.Berberine: a potential phytochemical with multispectrum therapeutic activities.Herb-drug pharmacokinetic interactions reviewed.Transporters, Trojan horses and therapeutics: suitability of bile acid and peptide transporters for drug delivery.Inhaled chemotherapy in lung cancer: future concept of nanomedicine.Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption.Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters.Novel pre-clinical methodologies for pharmacokinetic drug-drug interaction studies: spotlight on "humanized" animal models.The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors.Intestinal permeability and P-glycoprotein-mediated efflux transport of ticagrelor in Caco-2 monolayer cells.Comparing Various In Vitro Prediction Criteria to Assess the Potential of a New Molecular Entity to Inhibit Organic Anion Transporting Polypeptide 1B1.Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability.Single-vesicle estimation of ATP-binding cassette transporters in microfluidic channels.Development of a Novel Formulation That Improves Preclinical Bioavailability of Tenofovir Disoproxil Fumarate.Uptake/efflux transport of tramadol enantiomers and O-desmethyl-tramadol: focus on P-glycoprotein.Effects of omeprazole and ritonavir on absorption and elimination of the hepatitis C virus NS5A inhibitor GSK2336805 in healthy adults.Comparison of In Vitro Assays in Selecting Radiotracers for In Vivo P-Glycoprotein PET ImagingTransport of gemifloxacin, a 4th generation quinolone antibiotic, in the Caco-2 and engineered MDCKII cells, and potential involvement of efflux transporters in the intestinal absorption of the drug.Effects of Trichostatin A on drug uptake transporters in primary rat hepatocyte cultures.Bioavailability considerations in evaluating drug-drug interactions using the population pharmacokinetic approach.Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions.
P2860
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P2860
Scientific perspectives on drug transporters and their role in drug interactions.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Scientific perspectives on drug transporters and their role in drug interactions.
@ast
Scientific perspectives on drug transporters and their role in drug interactions.
@en
type
label
Scientific perspectives on drug transporters and their role in drug interactions.
@ast
Scientific perspectives on drug transporters and their role in drug interactions.
@en
prefLabel
Scientific perspectives on drug transporters and their role in drug interactions.
@ast
Scientific perspectives on drug transporters and their role in drug interactions.
@en
P2093
P356
P1476
Scientific perspectives on drug transporters and their role in drug interactions.
@en
P2093
John M Strong
Lawrence J Lesko
Shiew-Mei Huang
P356
10.1021/MP050095H
P407
P577
2006-01-01T00:00:00Z