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Lactose permease and the alternating access mechanismStructure of a prokaryotic virtual proton pump at 3.2 Å resolutionStructural determination of wild-type lactose permeaseCrystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognitionStructural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POTStructure-based mechanism for Na+/melibiose symport by MelBStructure of sugar-bound LacYCrystal structure of a bacterial homologue of glucose transporters GLUT1-4Evolutionary mix-and-match with MFS transportersEvolutionary mix-and-match with MFS transporters IILipids in the assembly of membrane proteins and organization of protein supercomplexes: implications for lipid-linked disordersRational mutational analysis of a multidrug MFS transporter CaMdr1p of Candida albicans by employing a membrane environment based computational approachBiochemical and molecular characterization of the gentisate transporter GenK in Corynebacterium glutamicumIdentification and functional characterization of novel xylose transporters from the cell factories Aspergillus niger and Trichoderma reeseiBasic residues R260 and K357 affect the conformational dynamics of the major facilitator superfamily multidrug transporter LmrPSubstrate-induced changes in the structural properties of LacYIntegration of evolutionary features for the identification of functionally important residues in major facilitator superfamily transportersToward the fourth dimension of membrane protein structure: insight into dynamics from spin-labeling EPR spectroscopySite-directed alkylation and the alternating access model for LacY.Sugar transport across lactose permease probed by steered molecular dynamics.Structural insights into the activation mechanism of melibiose permease by sodium binding.Dynamics of the L-fucose/H+ symporter revealed by fluorescence spectroscopy.Quantification of Detergents Complexed with Membrane ProteinsProbing of the rates of alternating access in LacY with Trp fluorescenceProtein localization in Escherichia coli cells: comparison of the cytoplasmic membrane proteins ProP, LacY, ProW, AqpZ, MscS, and MscL.Role of transmembrane domain 4 in ligand permeation by Crithidia fasciculata equilibrative nucleoside transporter 2 (CfNT2).Molecular modeling and ligand docking for solute carrier (SLC) transportersRole of Conserved Gly-Gly Pairs on the Periplasmic Side of LacY.Real-time conformational changes in LacY.Comparison of human solute carriersRandom mutagenesis of the prokaryotic peptide transporter YdgR identifies potential periplasmic gating residuesDirect observation of electrogenic NH4(+) transport in ammonium transport (Amt) proteins.Sugar binding induces the same global conformational change in purified LacY as in the native bacterial membrane.Suppression of conformation-compromised mutants of Salmonella enterica serovar Typhimurium MelB.Determination of the Na(+)/glucose cotransporter (SGLT1) turnover rate using the ion-trap technique.Cytoplasmic permeation pathway of neurotransmitter transporters.Opening the periplasmic cavity in lactose permease is the limiting step for sugar binding.A model-structure of a periplasm-facing state of the NhaA antiporter suggests the molecular underpinnings of pH-induced conformational changes.Probing the periplasmic-open state of lactose permease in response to sugar binding and proton translocation
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Lessons from lactose permease
@ast
Lessons from lactose permease
@en
type
label
Lessons from lactose permease
@ast
Lessons from lactose permease
@en
prefLabel
Lessons from lactose permease
@ast
Lessons from lactose permease
@en
P2860
P1476
Lessons from lactose permease
@en
P2093
P2860
P356
10.1146/ANNUREV.BIOPHYS.35.040405.102005
P577
2006-01-01T00:00:00Z