Perspective-- FcRn transports albumin: relevance to immunology and medicine.
about
Albumin-based drug delivery: harnessing nature to cure diseaseFc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeuticsUnraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based TherapeuticsThe neonatal Fc receptor, FcRn, as a target for drug delivery and therapySimple bioconjugate chemistry serves great clinical advances: albumin as a versatile platform for diagnosis and precision therapyModern Technologies for Creating Synthetic Antibodies for Clinical application.Human podocytes perform polarized, caveolae-dependent albumin endocytosis.Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptorAlbumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/2Unraveling the mysteries of serum albumin-more than just a serum protein.Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor.IgG subclasses and allotypes: from structure to effector functions.Co-opting biology to deliver drugsExtending half-life by indirect targeting of the neonatal Fc receptor (FcRn) using a minimal albumin binding domain.IgG is transported across the mouse yolk sac independently of FcgammaRIIb.Development and characterization of small bispecific albumin-binding domains with high affinity for ErbB3.Clinical ramifications of the MHC family Fc receptor FcRn.Abundant intracellular IgG in enterocytes and endoderm lacking FcRn.Novel exenatide analogs with peptidic albumin binding domains: potent anti-diabetic agents with extended duration of actionCharacterization and screening of IgG binding to the neonatal Fc receptor.Biodistribution and tumor imaging of an anti-CEA single-chain antibody-albumin fusion protein.Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2.Genetically engineered humanized mouse models for preclinical antibody studies.Serum N-Glycans: A New Diagnostic Biomarker for Light Chain Multiple Myeloma.Improved tumor imaging and therapy via i.v. IgG-mediated time-sequential modulation of neonatal Fc receptor.Monoclonal antibodies directed against human FcRn and their applications.Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugsCharacterization and Comparative Analysis of the Milk Transcriptome in Two Dairy Sheep Breeds using RNA SequencingProximal Tubules Have the Capacity to Regulate Uptake of Albumin.Prognostic utility of intact immunoglobulin Ig'κ/Ig'λ ratios in multiple myeloma patients.Pharmacokinetics of recombinant bifunctional fusion proteins.FcRn in the yolk sac endoderm of mouse is required for IgG transport to fetusRole of Fc Receptors as a therapeutic target.Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn.Evaluation of Evolocumab (AMG 145), a Fully Human Anti-PCSK9 IgG2 Monoclonal Antibody, in Subjects With Hepatic Impairment.Drug development: longer-lived proteins.Albumin and its application in drug delivery.The multiple facets of FcRn in immunity.Potential Sources of Inter-Subject Variability in Monoclonal Antibody Pharmacokinetics.Receptor-Mediated Endocytosis in the Proximal Tubule.
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P2860
Perspective-- FcRn transports albumin: relevance to immunology and medicine.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Perspective-- FcRn transports albumin: relevance to immunology and medicine.
@ast
Perspective-- FcRn transports albumin: relevance to immunology and medicine.
@en
type
label
Perspective-- FcRn transports albumin: relevance to immunology and medicine.
@ast
Perspective-- FcRn transports albumin: relevance to immunology and medicine.
@en
prefLabel
Perspective-- FcRn transports albumin: relevance to immunology and medicine.
@ast
Perspective-- FcRn transports albumin: relevance to immunology and medicine.
@en
P2093
P356
P1433
P1476
Perspective-- FcRn transports albumin: relevance to immunology and medicine.
@en
P2093
C L Bronson
Chaity Chaudhury
Clark L Anderson
Jonghan Kim
Manzoor A Wani
Sudhasri Mohanty
P304
P356
10.1016/J.IT.2006.05.004
P577
2006-05-30T00:00:00Z